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Leptomeningeal disease in oligodendroglial tumors: a population-based study
- Source :
- Journal of Neuro-Oncology
- Publisher :
- Springer Nature
-
Abstract
- In this population-based study, we determined the frequency and clinical characteristics of leptomeningeal disease (LMD) developing in the context of oligodendroglial tumors (oligodendrogliomas and oligoastrocytomas). LMD occurred in only 3.9% (8/204) of oligodendroglial tumors and in patients with more recurrences [mean 2.88 vs. 1.27 in LMD and non-LMD, respectively (p = 0.001)]. In contrast to LMD from systemic solid tumors, the median survival following the diagnosis of LMD in oligodendroglial tumors was surprisingly long at 22 months (95% CI 11–33 months). Treatment with oral chemotherapy seemed as effective as more aggressive treatments (e.g. repeat RT or intrathecal chemotherapy) in these patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Cancer Research
Neurology
Adolescent
Oligodendroglioma
Population
Clinical Neurology
Context (language use)
Community Health Planning
Young Adult
Meninges
Leptomeningeal spread
medicine
Humans
Oligodendroglial Tumor
Karnofsky Performance Status
Young adult
education
Aged
Retrospective Studies
Chromosome Aberrations
education.field_of_study
Brain Neoplasms
business.industry
Retrospective cohort study
Middle Aged
medicine.disease
medicine.anatomical_structure
Clinical Study – Patient Study
Oncology
Chromosomes, Human, Pair 1
Disease Progression
Female
Oligodendroglial tumors
Neurology (clinical)
Chromosome Deletion
business
Subjects
Details
- Language :
- English
- ISSN :
- 0167594X
- Volume :
- 104
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Neuro-Oncology
- Accession number :
- edsair.doi.dedup.....12c5d1c35f1de0765cc4014219bc7dd4
- Full Text :
- https://doi.org/10.1007/s11060-011-0551-3