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Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines
- Source :
- FEBS letters. 312(1)
- Publication Year :
- 1992
-
Abstract
- A beta subunit of the neuronal nicotinic receptor, sharing 88% homology with the rat beta 4 subunit, has been cloned from a human neuroblastoma cell line. The gene encoding the human beta 4 subunit is expressed in association with the alpha 3 gene in neuroblastoma and small-cell lung carcinoma cell lines. Patch-clamp experiments and radioligand binding assays confirm that these neuroendocrine tumor cell lines express functional neuronal nicotinic receptors. We suggest that these receptors might play a crucial role in the control of neurotransmitter and hormone secretion from neurosecretory human tumors.
- Subjects :
- medicine.medical_specialty
Lung Neoplasms
Macromolecular Substances
Molecular Sequence Data
Biophysics
Biology
Receptors, Nicotinic
Biochemistry
Polymerase Chain Reaction
Membrane Potentials
chemistry.chemical_compound
Neuroblastoma
Onium Compounds
Structural Biology
Internal medicine
Genetics
medicine
Tumor Cells, Cultured
Animals
Humans
Secretion
Amino Acid Sequence
Carcinoma, Small Cell
Receptor
Neurotransmitter
Molecular Biology
Neurons
Base Sequence
Sequence Homology, Amino Acid
Trityl Compounds
Cell Biology
Small-cell lung carcinoma
medicine.disease
Acetylcholine
Cell biology
Rats
Endocrinology
Nicotinic agonist
chemistry
Oligodeoxyribonucleotides
Cell culture
Carbachol
Small Cell Lung Carcinoma
Nicotine Receptor
Cloning
medicine.drug
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 312
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....12c1729007fa0d9926f3ef0c1b2d8884