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Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
- Source :
- Neurology. 68:1501-1508
- Publication Year :
- 2007
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2007.
-
Abstract
- Objective: To evaluate the total number of synapses in the stratum radiatum (str rad) of the human hippocampal CA1 subfield in individuals with mild Alzheimer disease (mAD), mild cognitive impairment (MCI), or no cognitive impairment (NCI) and determine if synapse loss is an early event in the progression of the disease. Methods: Short postmortem autopsy tissue was obtained, and an unbiased stereologic sampling scheme coupled with transmission electron microscopy was used to directly visualize synaptic contacts. Results: Individuals with mAD had fewer synapses (55%) than the other two diagnostic groups. Individuals with MCI had a mean synaptic value that was 18% lower than the NCI group mean. The total number of synapses showed a correlation with several cognitive tests including those involving both immediate and delayed recall. Total synaptic numbers showed no relationship to the subject9s Braak stage or to APOE genotype. The volume of the str rad was reduced in mAD vs the other two diagnostic groups that were not different from each other. Conclusion: These results strongly support the concept that synapse loss is a structural correlate involved very early in cognitive decline in mild Alzheimer disease (mAD) and supports mild cognitive impairment as a transitional stage between mAD and no cognitive impairment.
- Subjects :
- Male
Apolipoprotein E
Dendritic Spines
Presynaptic Terminals
Hippocampal formation
Hippocampus
Synapse
Central nervous system disease
Degenerative disease
Microscopy, Electron, Transmission
Alzheimer Disease
Predictive Value of Tests
medicine
Humans
Cognitive decline
Aged
Aged, 80 and over
Prognosis
medicine.disease
Cognitive test
Nerve Degeneration
Synapses
Disease Progression
Female
Neurology (clinical)
Alzheimer's disease
Cognition Disorders
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....12b85bcbf6b7ee508f641dae2e9640e5