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Concurrent neuroimaging and neurostimulation reveals a causal role for dlPFC in coding of task-relevant information
- Source :
- Communications Biology, Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group UK, 2021.
-
Abstract
- Dorsolateral prefrontal cortex (dlPFC) is proposed to drive brain-wide focus by biasing processing in favour of task-relevant information. A longstanding debate concerns whether this is achieved through enhancing processing of relevant information and/or by inhibiting irrelevant information. To address this, we applied transcranial magnetic stimulation (TMS) during fMRI, and tested for causal changes in information coding. Participants attended to one feature, whilst ignoring another feature, of a visual object. If dlPFC is necessary for facilitation, disruptive TMS should decrease coding of attended features. Conversely, if dlPFC is crucial for inhibition, TMS should increase coding of ignored features. Here, we show that TMS decreases coding of relevant information across frontoparietal cortex, and the impact is significantly stronger than any effect on irrelevant information, which is not statistically detectable. This provides causal evidence for a specific role of dlPFC in enhancing task-relevant representations and demonstrates the cognitive-neural insights possible with concurrent TMS-fMRI-MVPA.<br />Jade Jackson et al. use fMRI concurrent with transcranial magnetic stimulation (TMS) in an attention task to evaluate whether the right dorsolateral prefrontal cortex (dlPFC) is involved in facilitation of relevant information, or suppression of irrelevant information. Their results suggest that the dlPFC is causally involved in processing relevant information in an attention task and highlight the utility of a dual fMRI-TMS approach.
- Subjects :
- Male
genetic structures
medicine.medical_treatment
Medicine (miscellaneous)
0302 clinical medicine
Cortex (anatomy)
Task Performance and Analysis
Attention
Biology (General)
Brain Mapping
0303 health sciences
medicine.diagnostic_test
05 social sciences
Information processing
Representation (systemics)
article
Magnetic Resonance Imaging
Transcranial Magnetic Stimulation
3. Good health
medicine.anatomical_structure
Feature (computer vision)
Cognitive control
Facilitation
59/36
Female
General Agricultural and Biological Sciences
Psychology
psychological phenomena and processes
Cognitive psychology
Adult
QH301-705.5
Prefrontal Cortex
Neuroimaging
behavioral disciplines and activities
050105 experimental psychology
General Biochemistry, Genetics and Molecular Biology
Young Adult
03 medical and health sciences
medicine
Humans
0501 psychology and cognitive sciences
Neurostimulation
631/378/2649/2150
030304 developmental biology
Dorsolateral prefrontal cortex
Transcranial magnetic stimulation
631/378/2649/1310
nervous system
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Coding (social sciences)
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Communications Biology, Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
- Accession number :
- edsair.doi.dedup.....129e827593994da61ff302a2c6fa7982