Auto-antibody-negative limbic-like encephalitis as the first manifestation of Neurosyphilis

Syphilis is caused by the spirochete Treponema pallidum.When nvasion of the central nervous system (CNS) occurs, Neurosyphilis an develop and is able to imitate a wide variety of diseases with any clinical symptoms, including photophobia, headache, nausea nd cranial nerve palsies [1]. For instance Neurosyphilis can be the ause of simultaneous infarction in the territories of the posterior nferior cerebellar arteries [2]. Here we present a patient with an epileptic seizure on the asis of mesiotemporal encephalitis as the first manifestation of he disease and show that auto-antibodies typical of phenotypially similar CNS diseases were absent in this condition. This is of mportance, because in many patients it is usually not ruled out, hat encephalitis might be caused by auto-antibodies and Syphilis s only diagnosed by coincidence. This clinical course highlights the variety of clinical symptoms hatNeurosyphilis can causeand the importanceof considering this