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Nucleoside Analogues as Antibacterial Agents
- Source :
- Frontiers in Microbiology, Frontiers in Microbiology, Vol 10 (2019)
- Publication Year :
- 2019
- Publisher :
- Frontiers Media SA, 2019.
-
Abstract
- The rapid increase in antibiotic-resistant bacteria has emphasized the urgent need to identify new treatments for bacterial infections. One attractive approach, reducing the need for expensive and time-consuming clinical trials, is to repurpose existing clinically approved compounds for use as antibacterial agents. Nucleoside analogues are commonly used for treating viral and fungal infections, as well as for treating cancers, but have received relatively little attention as treatments for bacterial infections. However, a significant number of clinically approved derivatives of both pyrimidines and purines including halogenated, thiolated, and azolated compounds have been shown to have antibacterial activity. In the small number of studies carried out to date, such compounds have shown promise in treating bacterial infections. Here, we review the mechanisms of action and antibacterial activities of nucleoside analogues that can potentially be repurposed for treating infections as well as considering possible limitations in their usage.
- Subjects :
- Microbiology (medical)
antibiotic resistance
lcsh:QR1-502
multidrug-resistant bacteria
Purine analogue
antibacterial agents
Review
Pharmacology
Microbiology
lcsh:Microbiology
03 medical and health sciences
Pyrimidine analogue
Antibiotic resistance
Purine metabolism
030304 developmental biology
0303 health sciences
biology
pyrimidine analogues
030306 microbiology
Chemistry
biology.organism_classification
Antimicrobial
repurposed antibiotics
antimicrobial
Antibacterial activity
Nucleoside
purine analogues
Bacteria
Subjects
Details
- ISSN :
- 1664302X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Microbiology
- Accession number :
- edsair.doi.dedup.....12765b3964073b18566f7e5b6fcaf470