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Towards synchrotron phase-contrast lung imaging in patients – a proof-of-concept study on porcine lungs in a human-scale chest phantom
- Source :
- Journal of Synchrotron Radiation. 25:1827-1832
- Publication Year :
- 2018
- Publisher :
- International Union of Crystallography (IUCr), 2018.
-
Abstract
- In-line free propagation phase-contrast synchrotron tomography of the lungs has been shown to provide superior image quality compared with attenuation-based computed tomography (CT) in small-animal studies. The present study was performed to prove the applicability on a human-patient scale using a chest phantom with ventilated fresh porcine lungs. Local areas of interest were imaged with a pixel size of 100 µm, yielding a high-resolution depiction of anatomical hallmarks of healthy lungs and artificial lung nodules. Details like fine spiculations into surrounding alveolar spaces were shown on a micrometre scale. Minor differences in artificial lung nodule density were detected by phase retrieval. Since we only applied a fraction of the X-ray dose used for clinical high-resolution CT scans, it is believed that this approach may become applicable to the detailed assessment of focal lung lesions in patients in the future.
- Subjects :
- CT scan
Nuclear and High Energy Physics
Swine
Image quality
Computed tomography
In Vitro Techniques
Proof of Concept Study
Artificial lung
Imaging phantom
lung
030218 nuclear medicine & medical imaging
law.invention
03 medical and health sciences
0302 clinical medicine
synchrotron
pulmonary nodule
law
Image Processing, Computer-Assisted
medicine
Animals
Humans
In patient
Instrumentation
Radiation
Lung
medicine.diagnostic_test
Phantoms, Imaging
business.industry
Nodule (medicine)
respiratory system
Synchrotron
medicine.anatomical_structure
030228 respiratory system
Anatomic Landmarks
medicine.symptom
Tomography, X-Ray Computed
Nuclear medicine
business
Algorithms
Synchrotrons
Subjects
Details
- ISSN :
- 16005775
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Synchrotron Radiation
- Accession number :
- edsair.doi.dedup.....126d2e36ea637a7868ed0ce8b585555c