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Towards synchrotron phase-contrast lung imaging in patients – a proof-of-concept study on porcine lungs in a human-scale chest phantom

Authors :
Diego Dreossi
Frauke Alves
Giuliana Tromba
Felix Wuennemann
Fulvia Arfelli
Christian Dullin
Marco Confalonieri
Philip Konietzke
Joachim Lotz
Hans-Ulrich Kauczor
Jonas Albers
Agostino Accardo
Wolfram Stiller
Maria Assunta Cova
Jürgen Biederer
Mark O. Wielpütz
Serena Pacilè
Willi L. Wagner
Wagner, Willi L.
Wuennemann, Felix
Pacilé, Serena
Albers, Jona
Arfelli, Fulvia
Dreossi, Diego
Biederer, Jurgen
Konietzke, Philip
Stiller, Wolfram
Wielpütz, Mark O.
Accardo, Agostino
Confalonieri, Marco
Cova, Maria
Lotz, Joachim
Alves, Frauke
Kauczor, Hans-Hulrich
Tromba, Giuliana
Dullin, Christian
Source :
Journal of Synchrotron Radiation. 25:1827-1832
Publication Year :
2018
Publisher :
International Union of Crystallography (IUCr), 2018.

Abstract

In-line free propagation phase-contrast synchrotron tomography of the lungs has been shown to provide superior image quality compared with attenuation-based computed tomography (CT) in small-animal studies. The present study was performed to prove the applicability on a human-patient scale using a chest phantom with ventilated fresh porcine lungs. Local areas of interest were imaged with a pixel size of 100 µm, yielding a high-resolution depiction of anatomical hallmarks of healthy lungs and artificial lung nodules. Details like fine spiculations into surrounding alveolar spaces were shown on a micrometre scale. Minor differences in artificial lung nodule density were detected by phase retrieval. Since we only applied a fraction of the X-ray dose used for clinical high-resolution CT scans, it is believed that this approach may become applicable to the detailed assessment of focal lung lesions in patients in the future.

Details

ISSN :
16005775
Volume :
25
Database :
OpenAIRE
Journal :
Journal of Synchrotron Radiation
Accession number :
edsair.doi.dedup.....126d2e36ea637a7868ed0ce8b585555c