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Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study
- Source :
- Revista Brasileira de Farmacognosia, Vol 29, Iss 6, Pp 744-748 (2019), Revista Brasileira de Farmacognosia v.29 n.6 2019, Revista Brasileira de Farmacognosia, Sociedade Brasileira de Farmacognosia (SBFgnosia), instacron:SBFGNOSIA
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism. Keywords: Excretion, Plasma concentration, Tissue distribution, Wine-processing technology
- Subjects :
- Chromatography
biology
010405 organic chemistry
Chemistry
Selected reaction monitoring
Excretion
lcsh:RS1-441
Mass spectrometry
biology.organism_classification
Orcinol
01 natural sciences
0104 chemical sciences
Curculigo orchioides
Hypoxidaceae
lcsh:Pharmacy and materia medica
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Tissue distribution
Wine-processing technology
Glucoside
Liquid chromatography–mass spectrometry
General Pharmacology, Toxicology and Pharmaceutics
Naringin
Plasma concentration
Subjects
Details
- Language :
- English
- Volume :
- 29
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Revista Brasileira de Farmacognosia
- Accession number :
- edsair.doi.dedup.....12698122dfba1e0c17d8211c42d835b5