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Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study

Determination of orcinol glucoside by LC-MS in Curculigo orchioides and its application to a pharmacokinetic study

Authors :
Xiao-hang Ren
Cheng-guo Ju
Tong tong Lv
Tian-zhu Jia
Guo-shun Shan
Bonan Liu
Source :
Revista Brasileira de Farmacognosia, Vol 29, Iss 6, Pp 744-748 (2019), Revista Brasileira de Farmacognosia v.29 n.6 2019, Revista Brasileira de Farmacognosia, Sociedade Brasileira de Farmacognosia (SBFgnosia), instacron:SBFGNOSIA
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

This study was designed to explore the pharmacokinetic regularity of the plasma concentration, tissue distribution and excretion of orcinol glucoside from aqueous extracts of raw and processed Curculigo orchioides Gaertn., Hypoxidaceae. The experiment first used an ultrahigh-performance liquid chromatography-tandem mass spectrometry approach with multiple reaction monitoring and a positive mode to separate orcinol glucoside from naringin to obtain the plasma concentration curves, bar graph of tissue distribution and excretion curves. These results might be beneficial for reasonable clinical application of C. orchioides and for further development of its wine and salt-processing mechanism. Keywords: Excretion, Plasma concentration, Tissue distribution, Wine-processing technology

Details

Language :
English
Volume :
29
Issue :
6
Database :
OpenAIRE
Journal :
Revista Brasileira de Farmacognosia
Accession number :
edsair.doi.dedup.....12698122dfba1e0c17d8211c42d835b5