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Stridor-related gray matter alterations in multiple system atrophy: A pilot study
- Source :
- Parkinsonism & Related Disorders. 62:226-230
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Introduction: The neuroanatomical substrate of stridor associated with Multiple System Atrophy (MSA) remains unclear. We evaluated stridor-related gray matter (GM) changes in MSA. Methods: 36 MSA patients underwent standardized nocturnal video-polysomnography and brain MRI. Differences in GM density between MSA patients with and without stridor and a sample of 22 matched healthy controls were evaluated with Voxel Based Morphometry protocol supplemented by a specific tool (SUIT) for analysing infratentorial structures. Results: Stridor was confirmed in 14 patients (10 MSA-cerebellar variant; 10 M; mean ± SD age = 61.6 ± 8.9years; disease duration = 5.2 ± 2.9years) and absent in 22 (11 MSA-cerebellar variant; 18 M; age = 61.4 ± 9.9years; disease duration = 4.8 ± 3.4years). Compared to MSA without stridor, patients with stridor showed higher GM density in the cerebellum (p < 0.05, corrected for the MSA-cerebellar variant and uncorrected when considering both MSA-variants) and lower in the striatum (p < 0.05, uncorrected). Conclusions: This preliminary study has demonstrated for the first time in MSA stridor-related GM changes in striatal and cerebellar regions. Abnormalities in these regions were previously reported in dystonic disorders affecting laryngeal muscles, suggesting the hypothesis that stridor pathophysiology is dystonia-related. These results need however to be confirmed in a larger sample of patients.
- Subjects :
- Adult
Male
Voxel based morphometry
0301 basic medicine
Cerebellum
Pathology
medicine.medical_specialty
Neurology
Polysomnography
Stridor
Pilot Projects
03 medical and health sciences
0302 clinical medicine
Atrophy
stomatognathic system
mental disorders
otorhinolaryngologic diseases
Humans
Medicine
Gray Matter
Aged
Respiratory Sounds
Retrospective Studies
Aged, 80 and over
business.industry
Brain
Multiple system atrophy
Voxel-based morphometry
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Pathophysiology
nervous system diseases
030104 developmental biology
medicine.anatomical_structure
nervous system
Laryngeal Muscle
Female
Neurology (clinical)
Geriatrics and Gerontology
medicine.symptom
business
030217 neurology & neurosurgery
Dystonic disorder
Subjects
Details
- ISSN :
- 13538020
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Parkinsonism & Related Disorders
- Accession number :
- edsair.doi.dedup.....12542f8cbd266c4b3b81f2ca6a4ac9b2