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Difference in the ascending reticular activating system between vegetative and minimally conscious states following traumatic brain injury
- Source :
- Neuroreport
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Objectives We investigated differences in the ascending reticular activating system (ARAS) between vegetative state (VS) and minimally conscious state (MCS) in patients with traumatic brain injury (TBI) by using diffusion tensor tractography. Methods We recruited TBI patients and normal subjects. We reconstructed the lower ARAS and five parts of upper ARAS [prefrontal cortex (PFC), premotor cortex, primary motor cortex, primary somatosensory cortex, and posterior parietal cortex]. Results Significant differences were observed in the fractional anisotropy (FA) and fiber number (FN) values of the five parts of upper ARAS between the VS and control groups and between the MCS and control groups (P < 0.05), but no differences were detected in the lower ARAS (P > 0.05). The FA and FN values of the PFC in the upper ARAS were significantly different between the VS and MCS groups (P < 0.05). No other significant differences in FA and FN values were detected among the other segments of the upper ARAS or in the lower ARAS (P > 0.05). Conclusion The results indicate that the prefrontal portion of the upper ARAS is the critical area for distinguishing between VS and MCS in patients with TBI.
- Subjects :
- Adult
Male
medicine.medical_specialty
Traumatic brain injury
Posterior parietal cortex
Premotor cortex
Internal medicine
Brain Injuries, Traumatic
Neural Pathways
Fractional anisotropy
medicine
Humans
heterocyclic compounds
Prefrontal cortex
disorders of consciousness
Aged
ascending reticular activating system
diffusion tensor tractography
business.industry
traumatic brain injury
Persistent Vegetative State
General Neuroscience
food and beverages
Brain
Minimally conscious state
biochemical phenomena, metabolism, and nutrition
Middle Aged
diffusion tensor imaging
medicine.disease
Integrative Systems
carbohydrates (lipids)
medicine.anatomical_structure
Cardiology
lipids (amino acids, peptides, and proteins)
Female
Primary motor cortex
business
Reticular activating system
Subjects
Details
- ISSN :
- 09594965
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- NeuroReport
- Accession number :
- edsair.doi.dedup.....1253f766a0d446c6d9934efde1593767