Back to Search
Start Over
Heterogeneity of the haemagglutinin responses to Salmonella minnesota R-antigens in rabbits
- Source :
- Journal of general microbiology. 71(3)
- Publication Year :
- 1972
-
Abstract
- Summary: Homologous and heterologous haemagglutinin responses in rabbits to heat-killed R-mutants of Salmonella minnesota (chemotypes ranging from Ra to Re) were measured throughout the course of immunization. In each case the strongest response was directed against the homologous R-antigen, but in most cases cross-reactions with antigens of heterologous R-chemotypes were detected. Absorption studies with erythrocytes coated with R-lipopolysaccharides indicated that haemagglutinin reactions with homologous and heterologous R-antigens in R-antisera were due to several different populations of antibodies. In general, these populations consisted of: (i) antibodies strictly specific for the homologous antigen; (ii) antibodies reacting with the homologous antigen, but also able to react in varying degrees with heterologous R-lipopolysacharides of more complete chemo-types; (iii) antibodies directed against internal portions of the R-oligosaccharide; and (iv) antibodies strictly specific for a less complete form of the R-oligosaccharide molecule. Characteristic responses were obtained for each of the R-mutants with respect to the presence or absence of any one of the above-mentioned antibody populations in antisera at a given period after immunization.
- Subjects :
- Lipopolysaccharides
Erythrocytes
Heterologous
Biology
Cross Reactions
Microbiology
Antigen
Antibody Specificity
Homologous antigen
Homologous chromosome
Animals
Antiserum
Salmonella minnesota
Antigens, Bacterial
Salmonella Infections, Animal
Immune Sera
Polysaccharides, Bacterial
Hemagglutination Inhibition Tests
Virology
Immunization
Antibody Formation
Mutation
biology.protein
Rabbits
Antibody
Subjects
Details
- ISSN :
- 00221287
- Volume :
- 71
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of general microbiology
- Accession number :
- edsair.doi.dedup.....124157f92382ff0513269b835a99c22a