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Effects of depot testosterone therapy on serum levels of luteinizing hormone and follicle-stimulating hormone in patients with Klinefelter's syndrome and hypogonadotropic eunuchoidism
Effects of depot testosterone therapy on serum levels of luteinizing hormone and follicle-stimulating hormone in patients with Klinefelter's syndrome and hypogonadotropic eunuchoidism
- Source :
- The Journal of clinical endocrinology and metabolism. 39(5)
- Publication Year :
- 1974
-
Abstract
- In patients with Klinefelter's syndrome (KS) serum levels of testosterone (T) were scattered within a wide range and about half were within the normal range. A similar scattering was noted in elevated levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in these patients. On the other hand, serum levels of LH, FSH and T in patients with hypogonadotropic eunuchoidism (HE) were consistently low, remaining at prepubertal levels. In patients with KS who were receiving long-term treatment with T injections serum LH and FSH remained elevated, whereas in patients with HE after the treatment LH and FSH levels were significantly lower than those before treatment. Short-term studies of serum T, LH and FSH levels after a single im T injection revealed that in patients with KS suppression of serum gonadotropins occurred only transiently and modestly, while a normal man had rapid suppression of serum LH and FSH levels to substantially undetectable levels. Long-term studies were made in ca...
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Hypogonadotropic eunuchoidism
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Radioimmunoassay
Tritium
Biochemistry
Follicle-stimulating hormone
Endocrinology
Klinefelter Syndrome
Internal medicine
medicine
Humans
In patient
Eunuchism
Testosterone
S syndrome
business.industry
Biochemistry (medical)
Luteinizing Hormone
Middle Aged
Follicle Stimulating Hormone
Luteinizing hormone
business
hormones, hormone substitutes, and hormone antagonists
Hormone
Subjects
Details
- ISSN :
- 0021972X
- Volume :
- 39
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....12406c2928ed4a3135dbe35e5bc2ba16