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Effects of depot testosterone therapy on serum levels of luteinizing hormone and follicle-stimulating hormone in patients with Klinefelter's syndrome and hypogonadotropic eunuchoidism

Effects of depot testosterone therapy on serum levels of luteinizing hormone and follicle-stimulating hormone in patients with Klinefelter's syndrome and hypogonadotropic eunuchoidism

Authors :
Katsumi Wakabayashi
Koichiro Isurugi
Bun-Ichi Tamaoki
Keiko Fukutani
Hisao Takayasu
Source :
The Journal of clinical endocrinology and metabolism. 39(5)
Publication Year :
1974

Abstract

In patients with Klinefelter's syndrome (KS) serum levels of testosterone (T) were scattered within a wide range and about half were within the normal range. A similar scattering was noted in elevated levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in these patients. On the other hand, serum levels of LH, FSH and T in patients with hypogonadotropic eunuchoidism (HE) were consistently low, remaining at prepubertal levels. In patients with KS who were receiving long-term treatment with T injections serum LH and FSH remained elevated, whereas in patients with HE after the treatment LH and FSH levels were significantly lower than those before treatment. Short-term studies of serum T, LH and FSH levels after a single im T injection revealed that in patients with KS suppression of serum gonadotropins occurred only transiently and modestly, while a normal man had rapid suppression of serum LH and FSH levels to substantially undetectable levels. Long-term studies were made in ca...

Details

ISSN :
0021972X
Volume :
39
Issue :
5
Database :
OpenAIRE
Journal :
The Journal of clinical endocrinology and metabolism
Accession number :
edsair.doi.dedup.....12406c2928ed4a3135dbe35e5bc2ba16