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Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology
- Source :
- Chemosphere. 258:127409
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Perfluorobutanesulfonate (PFBS), an aquatic pollutant of emerging concern, is found to disturb gut microbiota, retinoid metabolism and visual signaling in teleosts, while probiotic supplementation can shape gut microbial community to improve retinoid absorption. However, it remains unknown whether probiotic bacteria can modulate the toxicities of PFBS on retinoid metabolism and visual physiology. In the present study, adult zebrafish were exposed for 28 days to 0, 10 and 100 μg/L PFBS, with or without dietary administration of probiotic Lactobacillus rhamnosus. Interaction between PFBS and probiotic was examined regarding retinoid dynamics (intestine, liver and eye) and visual stimuli transmission. PFBS single exposures remarkably inhibited the absorption of retinyl ester in female intestines, which were, however, restored by probiotic to normal status. Although coexposure scenarios markedly increased the hepatic storage of retinyl ester in females, mobilization of retinol was reduced in livers by single or combined exposures regardless of sex. In the eyes, transport and catalytic conversion of retinol to retinal and retinoic acid were interrupted by PFBS alone, which were efficiently antagonized by probiotic presumably through an indirect action. In response to the availability of retinal chromophore, transcriptions of opsins and arrestin genes were altered adaptively to control visual perception and termination. Neurotransmission across retina circuitry was changed accordingly, centering on epinephrine and norepinephrine. In summary, the present study found the efficient modulation of probiotic on retinoid metabolic disorders of PFBS pollution, which subsequently impacted visual signaling. A future work is warranted to provide mechanistic clues in retinoid interaction.
- Subjects :
- Environmental Engineering
Transcription, Genetic
genetic structures
medicine.drug_class
Health, Toxicology and Mutagenesis
0208 environmental biotechnology
Retinoic acid
02 engineering and technology
010501 environmental sciences
Gut flora
Pharmacology
Eye
01 natural sciences
law.invention
Retinoids
Probiotic
chemistry.chemical_compound
law
medicine
Animals
Environmental Chemistry
Retinoid
Ocular Physiological Phenomena
Zebrafish
0105 earth and related environmental sciences
Fluorocarbons
Opsins
biology
Probiotics
Public Health, Environmental and Occupational Health
Retinol
Retinal
General Medicine
General Chemistry
Lipid Metabolism
biology.organism_classification
Pollution
020801 environmental engineering
chemistry
Toxicity
Female
Sulfonic Acids
Water Pollutants, Chemical
Signal Transduction
Subjects
Details
- ISSN :
- 00456535
- Volume :
- 258
- Database :
- OpenAIRE
- Journal :
- Chemosphere
- Accession number :
- edsair.doi.dedup.....123f337f6a22875248353f5f5daf0ee1