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Association between aflatoxin B1 occupational airway exposure and risk of hepatocellular carcinoma: a case-control study
- Source :
- Tumour Biology
- Publication Year :
- 2014
-
Abstract
- The aim of this study was to determine the airway exposure of sugar and papermaking factory workers to aflatoxin B1 (AFB1) and to explore the potential association between AFB1 airway exposure and the risk of hepatocellular carcinoma (HCC) in a case-control study. Dust samples were collected from the sugarcane bagasse warehouse, and presser and paper production workshops. Blood samples were collected from 181 workshop employees and 203 controls who worked outside the workshop. AFB1 albumin adducts were detected using a double antibody sandwich enzyme-linked immunosorbent assay (ELISA). To explore the association between AFB1 airway exposure and the risk of HCC, the medical records of 68 HCC patients who worked in a sugar and papermaking factory between January 1994 and December 2013 were analyzed. A questionnaire was used to collect information from 150 healthy controls who worked for the same company and lived near the factory. AFB1 was detected in the dust samples, but could not be detected in any of the rice samples. An analysis of serum samples revealed serum AFB1 albumin adducts in 102 (56.35 %) of the study participants. However, in the control group, only 12 (5.9 %) individuals had detectable levels of AFB1 albumin adducts. Those with airway exposure to Aspergillus flavus-contaminated dust had an elevated risk of HCC compared to those without exposure (odds ratio, 5.24; 95 % confidence interval, 2.77–9.88; P = 0.00). The findings of this study indicate that occupational AFB1 airway exposure might be associated with the risk of AFB1-related HCC among the population that was used in this study. Intervention programs aimed at reducing exposure to inhalational AFB1 are needed urgently. Additional suitably designed, multicenter, prospective studies using large samples are needed to further confirm the results.
- Subjects :
- Adult
Male
Paper
Pathology
medicine.medical_specialty
Cancer Research
Aflatoxin B1
Carcinoma, Hepatocellular
Hepatocellular carcinoma
Population
Enzyme-Linked Immunosorbent Assay
Aflatoxins
Risk Factors
Internal medicine
Albumins
Occupational Exposure
Manufacturing Industry
medicine
Carcinoma
Humans
Prospective cohort study
education
education.field_of_study
Inhalation Exposure
business.industry
Liver Neoplasms
Case-control study
Dust
General Medicine
Odds ratio
medicine.disease
Confidence interval
Saccharum
Airway exposure
Case-Control Studies
Female
business
Airway
Research Article
Subjects
Details
- ISSN :
- 14230380
- Volume :
- 35
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Accession number :
- edsair.doi.dedup.....122ffbb97c930674a62da2aa49270d77