Back to Search
Start Over
Prenatal immune priming in onchocerciasis-onchocerca volvulus-specific cellular responsiveness and cytokine production in newborns from infected mothers
- Source :
- Clinical and experimental immunology. 117(1)
- Publication Year :
- 1999
-
Abstract
- SUMMARYThis study investigated the effect of maternal Onchocerca volvulus infection on humoral and cellular responsiveness in newborn children and their mothers. Onchocerca volvulus-specific IgG isotypes and IgE were significantly elevated in infected mothers and their infants. One year post partum, O. volvulus-specific IgG4 was strongly reduced in children of infected mothers, while IgG1 responses weakened only slightly. Umbilical cord mononuclear blood cells (UCBC) and peripheral blood cells (PBMC) from mothers proliferated in response to phytohaemagglutinin (PHA), concanavalin A (Con A), and the bacterial antigens streptolysin-O (SL-O) or purified protein derivative (PPD). UCBC from neonates born to O. volvulus-infected mothers responded lower (P
- Subjects :
- Adult
Cellular immunity
Adolescent
Immunology
Antibodies, Protozoan
Onchocerciasis
Parasitemia
Immune system
Antigen
Pregnancy
parasitic diseases
Immunology and Allergy
Animals
Humans
Onchocerca
Microfilariae
Phytohaemagglutinin
Immunity, Cellular
biology
Infant, Newborn
Immunoglobulin E
Middle Aged
biology.organism_classification
Fetal Blood
Onchocerca volvulus
Fetal Diseases
Immunoglobulin G
Pregnancy Complications, Parasitic
Togo
Humoral immunity
biology.protein
Leukocytes, Mononuclear
Cytokines
Female
Original Article
Bacterial antigen
Disease Susceptibility
Immunity, Maternally-Acquired
Subjects
Details
- ISSN :
- 00099104
- Volume :
- 117
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental immunology
- Accession number :
- edsair.doi.dedup.....120db651ce0a63200a3906b7e63b4d19