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Effect of natalizumab on clinical and radiological disease activity in a French cohort of patients with relapsing-remitting multiple sclerosis
- Source :
- Journal of neurology. 259(6)
- Publication Year :
- 2011
-
Abstract
- “Disease activity free” in relapsing-remitting multiple sclerosis (RRMS) is a new concept introduced by the results of the AFFIRM study. Our objective was to analyze the clinical and radiological efficacy of natalizumab treatment in actual clinical practice and compare it with the post hoc analysis of the AFFIRM study. All patients with RRMS who began treatment with natalizumab at our two French MS centres between April 2007 and May 2008 were included and followed-up for at least 2 years. No measurable disease activity (“disease activity free”) was defined as no activity on clinical measures (no relapses and no sustained disability progression) and radiological measures (no gadolinium-enhancing lesions and no new T2-hyperintense lesions on cerebral MRI). A total of 193 patients were included. Natalizumab was discontinued in 25.9% of cases before the completion of 2 years of treatment. In our cohort, we observed patients with more severe disease than in the AFFIRM study. The proportion of patients remaining free of clinical activity during 2 years of treatment was lower than in the AFFIRM study (37.8% vs. 64.3%). The proportion of patients remaining free of radiological activity during 2 years of treatment was higher than in the AFFIRM study (68.9% vs. 57.7%), while the proportion of patients remaining free of disease activity during 2 years of treatment was comparable to the AFFIRM study (33.3% vs. 36.7%). Natalizumab seems to be as effective in a real-life setting as in pivotal and post hoc studies. The confirmation of such benefits is important because of the progressive multifocal leukoencephalopathy risk.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neurology
education
Antibodies, Monoclonal, Humanized
Cohort Studies
Young Adult
Natalizumab
Multiple Sclerosis, Relapsing-Remitting
Internal medicine
Post-hoc analysis
medicine
Humans
Prospective Studies
Neuroradiology
business.industry
Multiple sclerosis
Progressive multifocal leukoencephalopathy
Middle Aged
medicine.disease
Radiography
Treatment Outcome
Radiological weapon
Cohort
Physical therapy
Female
Neurology (clinical)
France
business
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 14321459
- Volume :
- 259
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of neurology
- Accession number :
- edsair.doi.dedup.....120d6dcd5969e765c6753edc9761d1f9