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Nucleotide frequencies in human genome and Fibonacci numbers

Authors :
Alex Itiro Shimabukuro
Michel Eduardo Beleza Yamagishi
MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA
ALEX ITIRO SHIMABUKURO, PUC-Campinas.
Source :
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice), Empresa Brasileira de Pesquisa Agropecuária (Embrapa), instacron:EMBRAPA
Publication Year :
2007

Abstract

This work presents a mathematical model that establishes an interesting connection between nucleotide frequencies in human single-stranded DNA and the famous Fibonacci's numbers. The model relies on two assumptions. First, Chargaff's second parity rule should be valid, and, second, the nucleotide frequencies should approach limit values when the number of bases is sufficiently large. Under these two hypotheses, it is possible to predict the human nucleotide frequencies with accuracy. It is noteworthy, that the predicted values are solutions of an optimization problem, which is commonplace in many nature's phenomena.<br />12 pages, 2 figures

Details

Language :
English
Database :
OpenAIRE
Journal :
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice), Empresa Brasileira de Pesquisa Agropecuária (Embrapa), instacron:EMBRAPA
Accession number :
edsair.doi.dedup.....120a77184abde3310513a00f749b72ff