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New phenylpropanoid-substituted and benzyl-substituted flavonols from Alangium chinense
- Source :
- Fitoterapia. 148:104792
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Two previously undescribed flavonols with phenylpropanoid or benzyl substitution, named alangsine A (1), and alangsine B (2), together with four known compounds (3-6) were isolated from the leaves of Alangium chinense. Alangsine A was a racemic mixture, which was further separated into two enantiomers via high-performance liquid chromatography on a chiral column. The absolute configurations of the enantiomer pairs were deduced from the circular dichroism (CD) spectra. The activity of the isolated compounds towards neuronal excitability was examined.
- Subjects :
- China
Circular dichroism
Flavonols
Stereochemistry
Phytochemicals
Primary Cell Culture
Neocortex
01 natural sciences
Alangium chinense
Drug Discovery
Animals
Calcium Signaling
Cells, Cultured
Chromatography, High Pressure Liquid
Neurons
Pharmacology
chemistry.chemical_classification
Alangiaceae
Molecular Structure
Phenylpropanoid
biology
010405 organic chemistry
Chemistry
Circular Dichroism
General Medicine
biology.organism_classification
0104 chemical sciences
Mice, Inbred C57BL
Plant Leaves
010404 medicinal & biomolecular chemistry
Racemic mixture
Enantiomer
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 148
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....11f56aec0e6103e50f1c98e85162a6ec