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Seizure outcomes of supratentorial brain tumor resection in pediatric patients
- Source :
- Neuro-oncology. 20(9)
- Publication Year :
- 2018
-
Abstract
- BACKGROUND: This study aims to identify the prevalence of and risk factors for seizure development after supratentorial brain tumor resection in pediatric patients. This could be used to guide the postoperative management and usage of anti-epileptic drugs (AEDs). METHODS: Retrospective study was conducted for patients between 0 and 21 years with supratentorial tumor resection between 2005 and 2015 at a single institution. RESULTS: Two hundred patients (114 males/86 females) were identified. Median age at resection (±SD) was 9.025 ± 5.720 years and mean follow-up was 4 ± 2 years. Resection was gross total in 82 patients (41%) and partial in 118 patients (59%); 66 patients (33%) experienced preoperative seizures, and 67 patients (34%) experienced postoperative seizures; 18 patients (27%) had early seizures, and 49 patients (73%) had late seizures. Univariate analysis identified risk factors for postoperative seizures as: preoperative seizures (P < 0.001), age less than 2 years (P = 0.003), temporal location (P < 0.001), thalamic location (P = 0.017), preoperative hyponatremia (P = 0.017), World Health Organization grade (P = 0.008), and pathology (P = 0.005). Multivariate regression identified 5 robust risk factors: temporal location (odds ratio [OR] 4.7, 95% CI: 1.7–13.3, P = 0.003), age 0.05). CONCLUSIONS: This study reveals 5 risk factors for postoperative seizures after resection of supratentorial tumors. These factors should be considered in postoperative management of these patients.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Tumor resection
Supratentorial region
Preoperative care
Neurosurgical Procedures
Resection
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Seizures
medicine
Humans
Single institution
Child
Retrospective Studies
Univariate analysis
business.industry
Brain Neoplasms
Supratentorial Neoplasm
Supratentorial Neoplasms
Retrospective cohort study
Prognosis
Surgery
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Female
Neurology (clinical)
business
Pediatric Neuro-Oncology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15235866
- Volume :
- 20
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Neuro-oncology
- Accession number :
- edsair.doi.dedup.....11ebf084df894e148e3f0010860c7e4f