Back to Search
Start Over
Network substrates of cognitive impairment in Alzheimer's Disease
- Source :
- Tait, L, Stothart, G, Coulthard, E, Brown, J T, Kazanina, N & Goodfellow, M 2019, ' Network substrates of cognitive impairment in Alzheimer's Disease ', Clinical Neurophysiology, vol. 130, no. 9, pp. 1581-1595 . https://doi.org/10.1016/j.clinph.2019.05.027
- Publication Year :
- 2019
-
Abstract
- OBJECTIVES: Functional and structural disconnection of the brain is a prevailing hypothesis to explain cognitive impairment in Alzheimer's Disease (AD). We aim to understand the link between alterations to networks and cognitive impairment using functional connectivity analysis and modelling.METHODS: EEG was recorded from 21 AD patients and 26 controls, mapped into source space using eLORETA, and functional connectivity was calculated using phase locking factor. The mini-mental state exam (MMSE) was used to assess cognitive impairment. A computational model was used to uncover mechanisms of altered functional connectivity.RESULTS: Small-worldness (SW) of functional networks decreased in AD and was positively correlated with MMSE score and the language sub-score. Reduced SW was a result of increased path lengths, predominantly localized to the temporal lobes. Combining observed differences in local oscillation frequency with reduced temporal lobe effective connectivity in the model could account for observed functional network differences.CONCLUSIONS: Temporal lobe disconnection plays a key role in cognitive impairment in AD.SIGNIFICANCE: We combine electrophysiology, neuropsychological scores, and computational modelling to provide novel insight into the relationships between the disconnection hypothesis and cognitive decline in AD.
- Subjects :
- Male
Cognitive Neuroscience
Disease
Electroencephalography
Brain and Behaviour
Alzheimer's Disease
050105 experimental psychology
Temporal lobe
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Physiology (medical)
medicine
Connectome
Dementia
Humans
0501 psychology and cognitive sciences
Cognitive Dysfunction
Computer Simulation
Cognitive decline
Cognitive impairment
Clinical Neuropsychology
Aged
medicine.diagnostic_test
05 social sciences
Neuropsychology
medicine.disease
Mental Status and Dementia Tests
Sensory Systems
Temporal Lobe
Neurology
Case-Control Studies
Female
Neurology (clinical)
Disconnection
Nerve Net
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18728952
- Volume :
- 130
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....11e476800dc164a08417531361e40592