Back to Search Start Over

The Value of Clinical Anatomy, Imaging, Breast Gland Surgery and Therapeutic Implications in Breast Cancer

Authors :
Gabriel Stătescu
Dragoș Valentin Crauciuc
Dragoș Munteanu
Marius Constantin Moraru
Andrei Scripcaru
Alin Horațiu Nedelcu
Dragoș Andrei Chiran
Mariana Postolache
Cristinel Ioan Stan
Anca Sava
Publication Year :
2023
Publisher :
Zenodo, 2023.

Abstract

Breast cancer is a common disease in women over the age of 50. The risk of breast cancer in women between the ages of 30 to 39 is 1 in 250 women, and in women between the ages of 40 to 49 is 1 in 70 women. Material and method: We analysed clinicopathological data of the breast cancer on a series of 32 cases that underwent surgery between 2020–2021 in General Surgery Department of ”Providenta” Hospital Iasi, Romania. This includes the mammary gland and the cellular-adipose tissue placed between the glandular lobes and lobules together with blood and lymphatic vessels, and nerves. The study was conducted after the surgery on the parts resected through it, but we also used the explorations performed for diagnosis and stage evaluation such as breast ultrasound, mammography, staging CT. The patients ranged between 58 and 71 years old and came from rural areas. The anatomopathological examination confirmed the preoperative diagnosis, the patients being referred to oncology for evaluation followed by adjuvant treatment. Results: The postoperative evolution was favourable, and no immediate postoperative complications were reported. Aspiration drainage was removed on average after 3 days. The average length of hospital stay was 7 days. Discussions: The surgery was performed using the Madden technique and was a radical mastectomy with axillary lymph node removal. This technique offers a very good loco-regional clearance from the oncological point of view because it resects in block the mammary gland, the adipose tissue next to it, the skin on a wide surface as well as the neighbouring fascial system, also preserving the pectoral muscle. The axillary lymph-adenectomy is complete, with no risk of intraoperative dissemination. Conclusion: Radical mastectomy with axillary lymph node removal using the Madden technique, performed in the beginning stage is a modern, effective surgery, easily supported by patients who were informed from the beginning, with an average duration of two hours and reduced postoperative complications<br />{"references":["Clough K.B., Kaufman G.J., Nos C. et al. Improving breast cancer surgery: a classification and quadrant per quadrant atlas for oncoplastic surgery. Ann Surg Oncol, 2010; 17:1375-1391. DOI: 10.1245/s10434-009-0792-y. 2) Volovat C, Volovat S.R., Vulpoi C., Dascălu C.G., Cărăuşu E.M. Quality of life of women receiving adjuvant hormonal treatment for breast cancer– a randomized trial comparing tamoxifen with aromatase inhibitors. Jurnalul de Chirurgie, Iaşi, 2011; 7(2): 193-202, [ISSN: 1584–9341]. 3) Anastasiadi Z., Lianos G.D., Ignatiadou E., Harissis H.V., Mitsis M. Breast cancer in young women: an overview. Updates Surg, 2017; 69(3): 313-317. doi: 10.1007/s13304-017-0424-1. 4) Kolak A., Kamińska M., Sygit K., Budny A., Surdyka D., Kukiełka-Budny B., Burdan F. Primary, and secondary prevention of breast cancer. Ann Agric Environ Med, 2017; 24(4): 549-553. doi: 10.26444/aaem/75943. 5) Goldhirsch A., Wood W.C., Coates A.S., Gelber R.D., Thürlimann B., Senn H.J. Panel members. Strategies for subtypes– dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the primary therapy of early breast cancer 2011. Ann Oncol, 2011, 22(8):1736–1747. https://doi.org/10.1093/ annonc/mdr304; PMID: 21709140 PMCID: PMC3144634. 6) Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2020. CA Cancer J Clin, 2020; 70(1):7-30. doi: 10.3322/caac. 21590. 7) Odle T.G. Precision Medicine in Breast Cancer. Radiol Technol, 2017; 88(4): 401M-421M. PMID: 28298516. 8) Fahad Ullah M. Breast Cancer: Current Perspectives on the Disease Status. Adv Exp Med Biol, 2019; 1152:51-64. doi: The Value of Clinical Anatomy, Imaging, Breast Gland Surgery and Therapeutic Implications in Breast Cancer IJMRA, Volume 06 Issue 01 Janaury 2023 www.ijmra.in Page 465 10.1007/978-3-030-20301-6_4. 9) Partene Vicoleanu Simona Alice. Stromal inflammatory cell phenotypes in breast cancer. PhD thesis, \"Grigore T. Popa\" University of Medicine and Pharmacy, Iasi, Romania, prof. univ. dr. Carasevici Eugen, 2012. 10) Iancu G., Vasile D., Iancu R.C., Daviţoiu D.V. \"Triple positive\" breast cancer–a novel category? Rom J Morphol Embryol, 2017, 58(1):21–26; PMID: 28523293. 11) Perou C.M., Sørlie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Rees C.A., Pollack J.R., Ross D.T., Johnsen H., Akslen L.A., Fluge O., Pergamenschikov A., Williams C., Zhu S.X., Lønning P.E., Børresen-Dale A.L., Brown P.O., Botstein D. Molecular portraits of human breast tumours. Nature, 2000, 406(6797): 747–752; https://doi.org/10.1038/35021093; PMID: 10963602. 12) 12.Eliyatkın N., Yalçın E., Zengel B., Aktaş S., Vardar E. Molecular classification of breast carcinoma: from traditional, oldfashioned way to a new age, and a new way. J Breast Health, 2015, 11(2):59–66. https://doi.org/10.5152/ tjbh.2015.1669; PMID: 28331693; PMCID: PMC5351488. 13) Volovat S., Apostol D., Volovat C., Cărăuşu M. Quality of Life of Women with Breast Cancer Treated in Adjuvant Setting with Tamoxifen or Aromatase Inhibitors. European Journal of Cancer, 2011; 47(Suppl. 1): S379. DOI: 10.1016/S0959- 8049(11)71605-7. 14) Edge S.B., Sheldon D.G. Counterpoint: sentinel lymph node biopsy is not indicated for ductal carcinoma in situ. J Natl Compr Netw, 2003; 1:207-212. doi: 10.6004/jnccn.2003.0019. 15) Silverstein M.J., Lagios M.D., Groshen S. et al. The influence of margin width on local control of ductal carcinoma in situ of breast. N Engl J Med 1999; 340:1455-1461. 16) Hashmi A.A., Aijaz S., Mahboob R., Khan S.M., Irfan M., Iftikhar N., Nisar M., Siddiqui M., Edhi M.M., Faridi N., Khan A. Clinicopathologic features of invasive metaplastic and micropapillary breast carcinoma: comparison with invasive ductal carcinoma of breast. BMC Res Notes, 2018, 11(1):531. https://doi.org/10.1186/s13104-018-3623-z PMID: 30064485 PMCID: PMC 6069771. 17) Chen A.C., Paulino A.C., Schwartz M.R., Rodriguez A.A., Bass B.L., Chang J.C., Teh B.S. Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. Br J Cancer, 2014, 111(3): 619– 622. https://doi.org/10.1038/bjc.2014.301; PMID: 24921921; PMCID: PMC 4119976. 18) Baucom D.H., Porter L.S., Kirby S.J. et al. Psychosocial issues confronting women with breast cancer. Breast Dis 2005; 23:103-113. doi: 10.3233/bd-2006-23114. 19) Arrigada R., Le W.G., Rochard F., Contesso G. Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. Institute Gustave Roussy, Brest Cancer Group. J Clin Oncol, 1996; 14(5):1558- 1564. doi: 10.1200/JCO.1996.14.5.1558. 20) Litière S., Werutsky G., Fentiman I.S., Rutgers E., Christiaens M.R., Van Limbergen E., Baaijens M.H., Bogaerts J., Bartelink H. Breast conserving therapy versus mastectomy for stage I-II breast cancer: 20 years of follow-up of the EORTC 10801 phase 3 randomised trial. Lancet Oncol, 2012; 13: 412-419. doi: 10.1016/S1470-2045(12)700 42-6. 21) Cărăuşu M., Bidard F.C., Callens C., Melaabi S., Jeannot E., Pierga J.Y., Cabel L. ESR1 mutations: a new biomarker in breast cancer. Expert Rev Mol Diagn. 2019; 19(7):599-611. doi: 10.1080/ 14737159.2019.1631799; PMID:31188645. There is an Open Access article, distributed"]}

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....11e291c15d1c9e4b5941f1fde619e4c0
Full Text :
https://doi.org/10.5281/zenodo.7593051