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Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 5, p e0217390 (2019)
- Publication Year :
- 2019
- Publisher :
- Public Library of Science, 2019.
-
Abstract
- ObjectiveThe special status accorded to elite athletes stems from their uncommon genetic potential to excel in world-class power sports (PS). Genetic polymorphisms have been reported to influence elite PS status. Reports of associations between the α-actinin-3 gene (ACTN3) R577X polymorphism and PS have been inconsistent. In light of new published studies, we perform a meta-analysis to further explore the roles of this polymorphism in PS performance among elite athletes.MethodsMulti-database literature search yielded 44 studies from 38 articles. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used in estimating associations (significance threshold was set at Pa ≤ 0.05) using the allele-genotype model (R and X alleles, RX genotype). Outlier analysis was used to examine its impact on association and heterogeneity outcomes. Subgroup analysis was race (Western and Asian) and gender (male/female)-based. Interaction tests were applied to differential outcomes between the subgroups, P-values of which were Bonferroni corrected (Pinteraction BC). Tests for sensitivity and publication bias were performed.ResultsSignificant overall R allele effects (OR 1.21, 95% CI 1.07-1.37, Pa = 0.002) were confirmed in the Western subgroup (OR 1.11, 95% CI 1.01-1.22, Pa = 0.02) and with outlier treatment (ORs 1.12-1.20, 95% CIs 1.02-1.30, Pa < 10-5-0.01). This treatment resulted in acquired significance of the RX effect in Asian athletes (OR 1.91, 95% CI 1.25-2.92, Pa = 0.003). Gender analysis dichotomized the RX genotype and R allele effects as significantly higher in male (OR 1.14, 95% CI 1.02-1.28, Pa = 0.02) and female (OR 1.58, 95% CI 1.21-2.06, Pa = 0.0009) athletes, respectively, when compared with controls. Significant R female association was improved with a test of interaction (Pinteraction BC = 0.03). The overall, Asian and female outcomes were robust. The R allele results were more robust than the RX genotype outcomes. No evidence of publication bias was found.ConclusionsIn this meta-analysis, we present clear associations between the R allele/RX genotype in the ACTN3 polymorphism and elite power athlete status. Significant effects of the R allele (overall analysis, Western and female subgroups) and RX genotype (Asians and males) were for the most part, results of outlier treatment. Interaction analysis improved the female outcome. These robust findings were free of publication bias.
- Subjects :
- Male
Heredity
Physiology
Social Sciences
Publication Ethics
Genome-wide association study
Running
0302 clinical medicine
Mathematical and Statistical Techniques
Loss of Function Mutation
Genotype
Human Performance
Medicine and Health Sciences
Medicine
Psychology
Actinin
Research Integrity
Multidisciplinary
Statistics
Genomics
Metaanalysis
Sports Science
Genetic Mapping
Codon, Nonsense
Meta-analysis
Physical Sciences
Female
Research Article
Sports
Science Policy
Science
Subgroup analysis
Variant Genotypes
Athletic Performance
Research and Analysis Methods
Polymorphism, Single Nucleotide
03 medical and health sciences
Sex Factors
Genetics
Genome-Wide Association Studies
Humans
Allele
Statistical Methods
Alleles
Genetic Association Studies
Behavior
business.industry
Biological Locomotion
Racial Groups
Biology and Life Sciences
Computational Biology
Human Genetics
030229 sport sciences
Publication bias
Odds ratio
Genome Analysis
Confidence interval
Genetic Loci
Recreation
business
030217 neurology & neurosurgery
Mathematics
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....11e253f7259bf57da5e00d0b4cd7c5c2