New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases

Authors :: Daria Mochly-Rosen
Marie-Helene Disatnik
Sunhee Hwang
Julio C.B. Ferreira
Source :: Journal of Molecular Medicine (Berlin, Germany), Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
Publication Year :: 2015
Publisher :: Springer Science and Business Media LLC, 2015.
Abstract: The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases.

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