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An unconventional pathway of mRNA cap formation by vesiculoviruses
- Source :
- Virus research. 162(1-2)
- Publication Year :
- 2011
-
Abstract
- mRNAs of vesicular stomatitis virus (VSV), a prototype of nonsegmented negative strand (NNS) RNA viruses (e.g., rabies, measles, mumps, Ebola, and Borna disease viruses), possess the 5′-terminal cap structure identical to that of eukaryotic mRNAs, but the mechanism of mRNA cap formation is distinctly different from the latter. The elucidation of the unconventional capping of VSV mRNA remained elusive for three decades since the discovery of the cap structure in some viral and eukaryotic mRNAs in 1975. Only recently our biochemical studies revealed an unexpected strategy employed by vesiculoviruses (VSV and Chandipura virus, an emerging arbovirus) to generate the cap structure. This article summarizes the historical and current research that led to the discovery of the novel vesiculoviral mRNA capping reaction.
- Subjects :
- Guanylyltransferase
RNA Caps
Cancer Research
viruses
Molecular Sequence Data
Arbovirus
Vesicular stomatitis Indiana virus
Article
Chandipura virus
Viral Proteins
Virology
medicine
Humans
Cap formation
Amino Acid Sequence
Polyribonucleotide Nucleotidyltransferase
Borna disease
Messenger RNA
biology
RNA
Vesiculovirus
biology.organism_classification
medicine.disease
Nucleotidyltransferases
Infectious Diseases
Vesicular stomatitis virus
RNA, Viral
Vesicular Stomatitis
Sequence Alignment
Subjects
Details
- ISSN :
- 18727492
- Volume :
- 162
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Virus research
- Accession number :
- edsair.doi.dedup.....11cd90850606a56d8995da428fce2eaf