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Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy
- Source :
- Journal of human hypertension. 17(5)
- Publication Year :
- 2003
-
Abstract
- Vascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies. We wanted to investigate the influence of vascular hypertrophy and insulin resistance on LV hypertrophy and its function in patients with hypertension. In 89 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured blood pressure; insulin sensitivity by hyperinsulinaemic euglucaemic clamp; minimal forearm vascular resistance (MFVR) by plethysmography; intima-media cross-sectional area of the common carotid arteries (IMA) by ultrasound; and LV mass, relative wall thickness (RWT), systolic function and diastolic filling by echocardiography after two weeks of placebo treatment. LV mass index correlated to IMA/height (r=0.36, P=0.001), serum insulin (r=−0.25, P
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Carotid Artery, Common
Systole
medicine.medical_treatment
Denmark
Heart Ventricles
Population
Statistics as Topic
Diastole
Geometry
Blood Pressure
Left ventricular hypertrophy
Essential hypertension
Ventricular Function, Left
Muscle hypertrophy
Insulin resistance
Sex Factors
Internal medicine
Internal Medicine
medicine
Humans
Insulin
education
Aged
education.field_of_study
Ventricular Remodeling
business.industry
Norway
Stroke Volume
Middle Aged
medicine.disease
United States
medicine.anatomical_structure
Echocardiography
Hypertension
Cardiology
Vascular resistance
Female
Hypertrophy, Left Ventricular
Vascular Resistance
Insulin Resistance
business
Blood Flow Velocity
Subjects
Details
- ISSN :
- 09509240
- Volume :
- 17
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of human hypertension
- Accession number :
- edsair.doi.dedup.....11c4e64b9226b472843603536dffa087