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Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft
- Source :
- Immunology Letters. 99:30-35
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Interleukin 18 (IL-18) is a potent proinflammatory cytokine involved in the host defence by upregulating both innate and acquired immune responses and may be of particular importance also in mechanisms of kidney allograft rejection. Immunohistochemical staining of protocol biopsies showed constitutive IL-18 expression in the epithelium of distal tubules with the induction of immunoreactivity in acute rejection patients where also proximal tubules, infiltrating leukocytes, and endothelium were strongly positive. Furthermore, serum levels of IL-18 were significantly elevated in patients with acute rejection of kidney allograft (1247+/-389 pg/l) as compared to patients with uncomplicated outcome of kidney transplantation (444+/-164 pg/l) and subjects with acute tubulointerstitial nephropathy (385+/-155 pg/l, p
- Subjects :
- Graft Rejection
Pathology
medicine.medical_specialty
Biopsy
Immunology
Kidney
Cell Line
Proinflammatory cytokine
Interferon-gamma
Immune system
medicine
Humans
Transplantation, Homologous
Immunology and Allergy
Kidney surgery
Kidney transplantation
business.industry
Interleukin-18
Kidney metabolism
Epithelial Cells
medicine.disease
Immunohistochemistry
Kidney Transplantation
Up-Regulation
Transplantation
medicine.anatomical_structure
RNA
Interleukin 18
business
Subjects
Details
- ISSN :
- 01652478
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Immunology Letters
- Accession number :
- edsair.doi.dedup.....11bd292191036de7e4f5ec996e8f793d