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Arterial stiffness is increased in patients with inflammatory bowel disease
- Source :
- Journal of hypertension. 30(9)
- Publication Year :
- 2012
-
Abstract
- Recent studies have reported early atherosclerosis in patients with inflammatory bowel disease (IBD). In these patients, the chronic low-grade inflammation may predispose to vascular remodelling and arterial stiffening. We aimed at studying arterial stiffness in IBD patients.Thirty-two IBD patients without cardiovascular risk factors and 32 matched controls were enrolled (age 19-49 years). SphygmoCor device (AtCor Medical, Sydney, Australia) was used to measure carotid-femoral and carotid-radial (muscular artery) pulse wave velocity (PWV), augmentation index and central blood pressure.Carotid-femoral PWV was higher in IBD patients than in controls (6.6 ± 1.4 vs. 6.0 ± 0.8 m/s, respectively, P 0.05), as well as carotid-radial PWV (8.5 ± 1.2 vs. 7.2 ± 1.0 m/s, P 0.001). Central pulse pressure was higher in IBD than in controls (32 ± 6 vs. 28 ± 7 mmHg, P 0.05). Aging was an important determinant of carotid-femoral PWV in both groups and carotid-radial PWV only in IBD patients. In fully adjusted model performed in both groups of patients considered as a whole, age was positively associated with carotid-femoral PWV [R(2) = 0.10; +0.05 m/s per 1 year of aging, 95% confidence interval (CI) 0.01-0.08 m/s, P 0.05], as well as IBD (R(2) = 0.10; +0.72 m/s if IBD present, 95% CI 0.19-1.26 m/s, P 0.05). In IBD patients, carotid-radial PWV was positively associated with the disease duration (R(2) = 0.20; +0.11 m/s per 1 year of aging, 95% CI 0.03-0.19 m/s, P 0.05).Arterial stiffness is increased in patients with IBD independently of conventional cardiovascular risk factors.
- Subjects :
- Adult
Male
medicine.medical_specialty
Physiology
Inflammatory bowel disease
Vascular remodelling in the embryo
Vascular Stiffness
Internal medicine
Internal Medicine
medicine
Humans
In patient
cardiovascular diseases
Vascular stiffness
PulseWave Velocity
Pulse wave velocity
business.industry
Case-control study
Middle Aged
medicine.disease
Inflammatory Bowel Diseases
Confidence interval
Surgery
Pulse pressure
Case-Control Studies
cardiovascular system
Cardiology
Arterial stiffness
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 14735598
- Volume :
- 30
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of hypertension
- Accession number :
- edsair.doi.dedup.....11b87c1e5a58a1e8ebe7a833d8906962