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Residual respiratory impairment after COVID-19 pneumonia

Authors :
Lombardi, Francesco
Calabrese, Angelo
Iovene, Bruno
Pierandrei, Chiara
Lerede, Marialessia
Varone, Francesco
Richeldi, Luca
Sgalla, Giacomo
Landi, Francesco
Gremese, Elisa
Bernabei, Roberto
Fantoni, Massimo
Gasbarrini, Antonio
Settanni, Carlo Romano
Benvenuto, Francesca
Bramato, Giulia
Carfi', Angelo
Ciciarello, Francesca
Lo Monaco, Maria Rita
Martone, Anna Maria
Marzetti, Emanuele
Carmen, Napolitano
Pagano, Francesco Cosimo
Rocchi, Sara
Rota, Elisabetta
Salerno, Andrea
Tosato, Matteo
Tritto, Marcello
Calvani, Riccardo
Catalano, Lucio
Anna, Picca
Giulia, Savera
Tamburrini, Enrica
Borghetti, Alberto
Simona Di Gianbenedetto
Murri, Rita
Cingolani, Antonella
Ventura, Giulio
Taddei, Eleonora
Davide, Moschese
Arturo, Ciccullo
Stella, Leonardo
Addolorato, Giovanni
Franceschi, Francesco
Gertrude, Mingrone
Zocco, Maria Assunta
Mauirizio, Sanguinetti
Cattani Franchi, Paola
Marchetti, Simona
Alessandro, Bizzarro
Lauria, Alessandra
Rizzo, Stanislao
Savastano, Maria Cristina
Gambini, Gloria
Maria Grazia Cozzupoli
Culiersi, Carola
Passali, Giulio Cesare
Paludetti, Gaetano
Galli, Jacopo
Crudo, Fabrizio
Giovanni Di Cintio
Ylenia, Longobardi
Laura, Tricarico
Santantonio, Mariaconsiglia
Buonsenso, Danilo
Valentini, Piero
Davide, Pata
Davide, Sinatti
De Rose, Cristina
Aangelo, Calabrese
Sani, Gabriele
Delfina, Janiri
Giulia, Giuseppin
Marzia, Molinaro
Modica, Marco
Natale, Luigi
Larici, Anna Rita
Marano, Riccardo
Annamaria, Paglionico
Petricca, Luca
Laura, Gigante
Gerlando, Natalello
Fedele, Anna Laura
Lizzio, Marco Maria
Santoliquido, Angelo
Santoro, Luca
Nesci, Antonio
Valentina, Popolla
Source :
BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-8 (2021), BMC Pulmonary Medicine
Publication Year :
2021

Abstract

Introduction The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing the potential for long-term respiratory sequelae in these patients. We assessed the respiratory function in a cohort of patients after recovering from SARS-Cov-2 infection, stratified according to PaO2/FiO2 (p/F) values. Method Approximately one month after hospital discharge, 86 COVID-19 patients underwent physical examination, arterial blood gas (ABG) analysis, pulmonary function tests (PFTs), and six-minute walk test (6MWT). Patients were also asked to quantify the severity of dyspnoea and cough before, during, and after hospitalization using a visual analogic scale (VAS). Seventy-six subjects with ABG during hospitalization were stratified in three groups according to their worst p/F values: above 300 (n = 38), between 200 and 300 (n = 30) and below 200 (n = 20). Results On PFTs, lung volumes were overall preserved yet, mean percent predicted residual volume was slightly reduced (74.8 ± 18.1%). Percent predicted diffusing capacity for carbon monoxide (DLCO) was also mildly reduced (77.2 ± 16.5%). Patients reported residual breathlessness at the time of the visit (VAS 19.8, p Conclusion Approximately one month after hospital discharge, patients with COVID-19 can have residual respiratory impairment, including lower exercise tolerance. The extent of this impairment seems to correlate with the severity of respiratory failure during hospitalization.

Details

Language :
English
Database :
OpenAIRE
Journal :
BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-8 (2021), BMC Pulmonary Medicine
Accession number :
edsair.doi.dedup.....11b2889dc7e33bbce55a5e9483e99c77