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Artificial membranes for membrane protein purification, functionality and structure studies

Authors :
Vincent L. G. Postis
Adrian Goldman
Stephen P. Muench
Carine De Marcos Lousa
Mayuriben J. Parmar
Source :
Biochemical Society Transactions. 44:877-882
Publication Year :
2016
Publisher :
Portland Press Ltd., 2016.

Abstract

Membrane proteins represent one of the most important targets for pharmaceutical companies. Unfortunately, technical limitations have long been a major hindrance in our understanding of the function and structure of such proteins. Recent years have seen the refinement of classical approaches and the emergence of new technologies that have resulted in a significant step forward in the field of membrane protein research. This review summarizes some of the current techniques used for studying membrane proteins, with overall advantages and drawbacks for each method.

Details

ISSN :
14708752 and 03005127
Volume :
44
Database :
OpenAIRE
Journal :
Biochemical Society Transactions
Accession number :
edsair.doi.dedup.....11a5345d755f175e0f51ed7326dec789
Full Text :
https://doi.org/10.1042/bst20160054