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Global organization of functional brain connectivity in methamphetamine abusers
- Source :
- Clinical Neurophysiology, 124, 1122-1131. Elsevier Ireland Ltd
- Publication Year :
- 2012
-
Abstract
- Objective This study aimed to determine effects of chronic methamphetamine (MA) abuse on global organization of the functional brain connectivity. Methods Eyes-closed resting-state EEGs of 36 MA abusers and 36 age-matched healthy subjects were recorded using a 32-channel system. The EEGs (1–60Hz), after removing artifacts, were decomposed into the conventional EEG bands. Using visibility graph similarity (VGS) and coherence methods, the VGS and coherence matrices in each EEG band were constructed. Then the Small-World Network properties, clustering coefficient ( C ), mean path length ( L ) and C / L , of the VGS and coherence matrices, were computed in all EEG bands. Then using the Mann–Whitney test and an artificial neural network the differences of C , L and C / L between the two groups were evaluated. Results The MA abusers showed higher C , lower L and higher C / L at the gamma band ( p -value Conclusions The topology of the functional brain connectivity is disrupted in MA abusers, as depicted by deviation from Small-Worldness in the gamma band. Significance This is the first but quasi-experimental study showing disrupted topology of the functional brain networks in MA abusers.
- Subjects :
- Adult
Male
Amphetamine-Related Disorders
Intelligence
Electroencephalography
Brain mapping
Functional Laterality
Developmental psychology
Methamphetamine
Functional brain
Young Adult
Similarity (network science)
Physiology (medical)
Neural Pathways
medicine
Cluster Analysis
Humans
Clustering coefficient
Brain Mapping
medicine.diagnostic_test
business.industry
Healthy subjects
Brain
Pattern recognition
Coherence (statistics)
Middle Aged
Sensory Systems
Neurology
Nonlinear Dynamics
Data Interpretation, Statistical
Central Nervous System Stimulants
Female
Neurology (clinical)
Artificial intelligence
Psychology
business
Algorithms
medicine.drug
Subjects
Details
- ISSN :
- 18728952 and 13882457
- Volume :
- 124
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....1198681294823a788da0f876a1b13a66