P05.89 Comparison of local control of brain metastases with stereotactic radiosurgery versus surgical resection: A secondary analysis of EORTC 22952–26001

BACKGROUND: We sought to evaluate local control of brain metastases among patients treated with stereotactic radiosurgery (SRS) versus neurosurgical resection within EORTC 22952. MATERIAL AND METHODS: We performed a post-hoc analysis of EORTC 22952 and included patients treated per-protocol who had 1–2 brain metastases = 9months, local control appeared superior for surgery: 0.36[0.14–0.93]. Increased risk of local recurrence was also associated with increasing tumor size (p=0.031) and absence of extracranial disease (p=0.044). CONCLUSION: In this exploratory analysis, SRS appeared associated with improved early local control of treated lesions compared to patients treated surgically, although the relative benefit decreased with time. Variation in baseline patient characteristics limit this analysis warranting further study.