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Ultrahypofractionated CyberKnifeTM based stereotactic radiotherapy versus conventional radiotherapy in patients with prostate cancer - acute toxicity evaluation in two phase II prospective studies
- Source :
- Neoplasma. 64(4)
- Publication Year :
- 2017
-
Abstract
- Our purpose was to compare the acute toxicity of ultrahypofractionated CyberKnifeTM based stereotactic radiotherapy (SBRT Arm) and conventional radiotherapy (EBRT Arm) in prostate cancer patients. Two-hundred-sixteen men with prostate cancer were enrolled in our prospective studies. One-hundred and nine were irradiated using CyberKnife to total dose of 36,25 Gy in 5 fractions. One-hundred and seven were irradiated conventionally to total dose of 76 Gy in 38 fractions. Mean age of patients was 69. Acute genitourinary (GU) and gastrointestinal (GI) adverse-events were collected. The maximal acute toxicity EORTC/RTOG score was assumed. A total of 41%, 44%, 12% and 3% of patients presented grade 0, 1, 2 and 3 acute genitourinary toxicity in SBRT arm, respectively. A total of 21%, 33%, 43% and 3% of patients demonstrated acute grade 0, 1, 2 and 3 genitourinary toxicity in EBRT arm. A significant difference between number of patients with grade 2 GU toxicity was observed (p-0.000) and between patients without any toxicity (p-0.0017).A significant difference in frequency of acute GI toxicity between both groups was observed, too. 71% vs. 44% had no toxicity (p-0.0001), and 3% vs. 18% (p-0.0004) presented grade 2 GI toxicity in SBRT and EBRT arms respectively.The acute toxicity rates of fractionated stereotactic radiotherapy is lower compared to conventional irradiation.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Radiosurgery
030218 nuclear medicine & medical imaging
Stereotactic radiotherapy
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Conventional radiotherapy
Cyberknife
Medicine
Humans
Prospective Studies
Prospective cohort study
Aged
business.industry
Genitourinary system
Prostatic Neoplasms
Radiotherapy Dosage
medicine.disease
Acute toxicity
Oncology
030220 oncology & carcinogenesis
Toxicity
Radiology
Dose Fractionation, Radiation
business
Subjects
Details
- ISSN :
- 00282685
- Volume :
- 64
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Neoplasma
- Accession number :
- edsair.doi.dedup.....1182236aee8f974b285b4573c4fc9b62