Back to Search
Start Over
Curatopes Melanoma: A Database of Predicted T-cell Epitopes from Overly Expressed Proteins in Metastatic Cutaneous Melanoma
- Source :
- Cancer Research. 79:5452-5456
- Publication Year :
- 2019
- Publisher :
- American Association for Cancer Research (AACR), 2019.
-
Abstract
- Therapeutic anticancer vaccination has been adapted as an immunotherapy in several solid tumors. However, the selection of promising candidates from the total quantity of possible epitopes poses a challenge to clinicians and bioinformaticians alike, and very few epitopes have been tested in experimental or clinical settings to validate their efficacy. Here, we present a comprehensive database of predicted nonmutated peptide epitopes derived from genes that are overly expressed in a group of 32 melanoma biopsies compared with healthy tissues and that were filtered against expression in a curated list of survival-critical tissues. We hypothesize that these "self-tolerant" epitopes have two desirable properties: they do not depend on mutations, being immediately applicable to a large patient collective, and they potentially cause fewer autoimmune reactions. To support epitope selection, we provide an aggregated score of expected therapeutic efficiency as a shortlist mechanism. The database has applications in facilitating epitope selection and trial design and is freely accessible at https://www.curatopes.com. Significance: A database is presented that predicts and scores antitumor T-cell epitopes, with a focus on tolerability and avoidance of severe autoimmunity, offering a supplementary epitope set for further investigation in immunotherapy.
- Subjects :
- 0301 basic medicine
Cancer Research
Skin Neoplasms
medicine.medical_treatment
Epitopes, T-Lymphocyte
Autoimmunity
computer.software_genre
medicine.disease_cause
Epitope
03 medical and health sciences
0302 clinical medicine
Antigen
Antigens, Neoplasm
Immune Tolerance
Humans
Medicine
Databases, Protein
Melanoma
Gene
Database
business.industry
Mechanism (biology)
Immunotherapy
medicine.disease
Neoplasm Proteins
Vaccination
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Tumor Escape
Peptides
business
computer
T-Lymphocytes, Cytotoxic
Subjects
Details
- ISSN :
- 15387445 and 00085472
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Cancer Research
- Accession number :
- edsair.doi.dedup.....117b2e75a86ce76827c47ff942667d6b