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Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin-induced cardio toxicity via suppressing oxidative stress and apoptosis
- Source :
- IUBMB lifeREFERENCES. 72(4)
- Publication Year :
- 2019
-
Abstract
- We investigated the rosiglitazone (RSG) effect on adriamycin (ADM)-induced cardio toxicity in experimental animals. Forty adult Wistar male rats were separated into four groups as follows: normal control; RSG (10 mg/kg)-treated; ADM (10 mg/kg)-administered; and ADM (10 mg/kg) + RSG (10 mg/kg)-treated. Serum lipid level, different biochemical biomarkers, histological analysis, and nuclear factor erythroid 2-related factor/heme oxygenase-1 (Nrf2/HO-1), Caspase 3, B-cell lymphoma 2 (Bcl-2), and Bax gene expression were assessed in serum and cardiac tissue samples. Our results show that RSG treatment in ADM-administered animals significantly diminished low-density lipoprotein cholesterol, triglyceride, and total cholesterol, and increases high-density lipoprotein cholesterol (HDL-c) in comparison with the ADM group. RSG treatment reduced the effect of ADM administration on cardiac dysfunction markers such as cardiac troponin T Creatine Kinase-MB, aspartate aminotransferase, and lactate dehydrogenase, showing the amelioration of cardio toxicity in ADM-administered rats. Additionally, RSG treatment significantly decreased the level of malondialdehyde and nitric oxide in cardiovascular tissue. RSG-treated rats in combination with ADM likewise showed a significant increase in reduced glutathione, superoxide dismutase, catalase content, and the activity of glutathione peroxidase (GPx) as compared with ADM group. Moreover, RSG treatment in ADM rats significantly increased an Nrf2 and HO-1 expression in comparison with ADM group. While in apoptosis parameters, RSG treatment in ADM rats significantly diminished a cleaved caspase-3 and Bax expression as well as expanded Bcl-2 expression when contrasted with ADM group of rats. In conclusion, RSG is capable of protecting heart toxicity in ADM-treated animals through defensive effects on oxidative stress and biochemical markers.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Cardiotonic Agents
Clinical Biochemistry
Apoptosis
Creatine
medicine.disease_cause
Biochemistry
Cardiotoxins
Rosiglitazone
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Lactate dehydrogenase
Genetics
medicine
Animals
Rats, Wistar
Molecular Biology
bcl-2-Associated X Protein
chemistry.chemical_classification
Glutathione peroxidase
Myocardium
Heart
Cell Biology
Glutathione
Malondialdehyde
Lipids
PPAR gamma
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
Gene Expression Regulation
Doxorubicin
030220 oncology & carcinogenesis
Toxicity
Heme Oxygenase (Decyclizing)
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 15216551
- Volume :
- 72
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- IUBMB lifeREFERENCES
- Accession number :
- edsair.doi.dedup.....1172f2048c1f23e6fa00470b3ca580e0