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Procalcitonin as a biomarker of bacterial infection in pediatric patients after congenital heart surgery
- Source :
- Annals of Pediatric Cardiology, Annals of Pediatric Cardiology, Vol 9, Iss 2, Pp 115-119 (2016)
- Publication Year :
- 2016
-
Abstract
- Background: Bacterial infection (BI) after congenital heart surgery (CHS) is associated with increased morbidity and is difficult to differentiate from systemic inflammatory response syndrome caused by cardiopulmonary bypass (CPB). Procalcitonin (PCT) has emerged as a reliable biomarker of BI in various populations. Aim: To determine the optimal PCT threshold to identify BI among children suspected of having infection following CPB. Setting and Design: Single-center retrospective observational study. Materials and Methods: Medical records of all the patients admitted between January 2013 and April 2015 were reviewed. Patients in the age range of 0-21 years of age who underwent CHS requiring CPB in whom PCT was drawn between postoperative days 0-8 due to suspicion of infection were included. Statistical Analysis: The Wilcoxon rank-sum test was used for nonparametric variables. The diagnostic performance of PCT was evaluated using a receiver operating characteristic (ROC) curve. Results: Ninety-eight patients were included. The median age was 2 months (25th and 75th interquartile of 0.1-7.5 months). Eleven patients were included in the BI group. The median PCT for the BI group (3.42 ng/mL, 25th and 75th interquartile of 2.34-5.67) was significantly higher than the median PCT for the noninfected group (0.8 ng/mL, 25th and 75th interquartile 0.38-3.39), P = 0.028. The PCT level that yielded the best compromise between the sensitivity (81.8%) and specificity (66.7%) was 2 ng/mL with an area under the ROC curve of 0.742. Conclusion: A PCT less than 2 ng/mL makes BI unlikely in children suspected of infection after CHS.
- Subjects :
- medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
congenital heart surgery
lcsh:Medicine
030204 cardiovascular system & hematology
Procalcitonin
law.invention
03 medical and health sciences
0302 clinical medicine
procalcitonin (PCT)
law
Interquartile range
parasitic diseases
Cardiopulmonary bypass
Medicine
030212 general & internal medicine
Receiver operating characteristic
business.industry
lcsh:R
lcsh:RJ1-570
Retrospective cohort study
lcsh:Pediatrics
Cardiac surgery
medicine.disease
infection
Surgery
Systemic inflammatory response syndrome
pediatric
lcsh:RC666-701
Pediatrics, Perinatology and Child Health
Biomarker (medicine)
Original Article
cardiopulmonary bypass (CPB)
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 09742069
- Volume :
- 9
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Annals of pediatric cardiology
- Accession number :
- edsair.doi.dedup.....11619be27af724289df2fbbe93215af9