Back to Search
Start Over
An overview of anti-epileptic therapy management of patients with malignant tumors of the brain undergoing radiation therapy
- Source :
- Seizure. 70
- Publication Year :
- 2019
-
Abstract
- As our surgical, radiation, chemotherapeutic and supportive therapies for brain malignancies improve, and overall survival is prolonged, appropriate symptom management in this patient population becomes increasingly important. This review summarizes the published literature and current practice patterns regarding prophylactic and perioperative anti-epileptic drug use. As a wide range of anti-epileptic drugs is now available to providers, evidence guiding appropriate anticonvulsant choice is reviewed. A particular focus of this article is radiation therapy for brain malignancies. Toxicities and seizure risk associated with cranial irradiation will be discussed. Epilepsy management in patients undergoing radiation for gliomas, glioblastoma multiforme, and brain metastases will be addressed. An emerging but inconsistent body of evidence, reviewed here, indicates that anti-epileptic medications may increase radiosensitivity, and therefore improve clinical outcomes, specifically in glioblastoma multiforme patients.
- Subjects :
- Drug
medicine.medical_specialty
medicine.medical_treatment
media_common.quotation_subject
Brain tumor
03 medical and health sciences
Epilepsy
0302 clinical medicine
Seizures
Glioma
medicine
Humans
External beam radiotherapy
Intensive care medicine
media_common
business.industry
Brain Neoplasms
Disease Management
General Medicine
Perioperative
medicine.disease
Radiation therapy
Therapy management
Neurology
Anticonvulsants
Neurology (clinical)
Cranial Irradiation
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15322688
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Seizure
- Accession number :
- edsair.doi.dedup.....1159563be496ff32ee5939205028a6c9