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Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts
- Source :
- Oncotarget, Oncotarget, 7 (46, ONCOTARGET
- Publication Year :
- 2016
- Publisher :
- Impact Journals LLC, 2016.
-
Abstract
- In patients with rectal prolapse is the prevalence of colorectal cancer increased, suggesting that a colorectal tumor may induce rectal prolapse. Establishment of tumor xenografts in immunodeficient mice after orthotopic inoculations of human colorectal cancer cells into the caecal wall is a widely used approach for the study of human colorectal cancer progression and preclinical evaluation of therapeutics. Remarkably, 70% of young mice carrying a COLO320DM caecal tumor showed symptoms of intussusception of the large bowel associated with intestinal lumen obstruction and rectal prolapse. The quantity of the COLO320DM bioluminescent signal of the first three weeks post-inoculation predicts prolapse in young mice. Rectal prolapse was not observed in adult mice carrying a COLO320DM caecal tumor or young mice carrying a HT29 caecal tumor. In contrast to HT29 tumors, which showed local invasion and metastasis, COLO320DM tumors demonstrated a non-invasive tumor with pushing borders without presence of metastasis. In conclusion, rectal prolapse can be linked to a non-invasive, space-occupying COLO320DM tumor in the gastrointestinal tract of young immunodeficient mice. These data reveal a model that can clarify the association of patients showing rectal prolapse with colorectal cancer.<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- Oncology
Colorectal cancer
THERAPY
Gastroenterology
Metastasis
Orthotopic
Mice
0302 clinical medicine
Intussusception (medical disorder)
Medicine and Health Sciences
Medicine
IN-VIVO
Gastrointestinal tract
Age Factors
Middle Aged
NUDE-MICE
3. Good health
Tumor Burden
030220 oncology & carcinogenesis
Heterografts
030211 gastroenterology & hepatology
Female
Colorectal Neoplasms
Research Paper
medicine.medical_specialty
mouse model
INHIBITION
Context (language use)
colorectal cancer
Mouse model
03 medical and health sciences
In vivo
Internal medicine
Cell Line, Tumor
Animals
Humans
In patient
ULCER SYNDROME
orthotopic
Rectal prolapse
business.industry
COLO320DM
Rectal Prolapse
medicine.disease
ENDOTHELIAL-CELLS
HUMAN-COLON-CARCINOMA
Disease Models, Animal
METASTASIS
INTUSSUSCEPTION
GROWTH-FACTOR RECEPTOR
business
Psychiatrie
Subjects
Details
- Language :
- English
- ISSN :
- 19492553
- Volume :
- 7
- Issue :
- 46
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....115491b4f5bd33179a305b3316e5e655