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Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D2-receptor occupancy method in the rat
- Source :
- European Journal of Pharmacology. 540:87-90
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The purpose of the present study was to determine antipsychotic doses that achieve 80% striatal dopamine D2-receptor occupancy for haloperidol, risperidone and olanzapine in rats. Wistar rats were treated with normal saline vehicle (controls), haloperidol (0.25 and 0.5 mg/kg/day), risperidone (3, 5 and 6 mg/kg/day) and olanzapine (5 and 10 mg/kg/day) for 7 days via osmotic minipumps. Striatal and cerebellar tissue were collected and in vivo dopamine D2-receptor occupancies were determined using 3H-raclopride. The doses required to achieve dopamine D2-receptor occupancy of 80% in 11- and 24-week old rats were: haloperidol 0.25 mg/kg/day, risperidone 5 mg/kg/day and olanzapine 10 mg/kg/day.
- Subjects :
- Male
Olanzapine
medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Atypical antipsychotic
Pharmacology
Tritium
Binding, Competitive
Benzodiazepines
Radioligand Assay
Cerebellum
Dopamine receptor D2
Internal medicine
Haloperidol
Animals
Medicine
Rats, Wistar
Antipsychotic
Raclopride
Analysis of Variance
Risperidone
Dose-Response Relationship, Drug
Receptors, Dopamine D2
business.industry
Dopamine antagonist
Corpus Striatum
Rats
Endocrinology
business
Algorithms
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 540
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....114e3123455db351113e026c7d113a18