Back to Search
Start Over
Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampus
- Source :
- Neuroscience letters. 403(1-2)
- Publication Year :
- 2006
-
Abstract
- The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia. RGS8 mRNA expression started to increase at a later time point in the CA3 region but no changes were found for RGS2. Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus.
- Subjects :
- Male
medicine.medical_specialty
General Neuroscience
Dentate gyrus
Ischemia
Hippocampus
In situ hybridization
Biology
medicine.disease
Gerbil
Brain Ischemia
Endocrinology
nervous system
Internal medicine
Gene expression
medicine
Animals
sense organs
RNA, Messenger
Receptor
Gerbillinae
RGS2
RGS Proteins
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 403
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....1141c12f052dc562fac77d579ba4a426