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Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules
- Source :
- Fertility and Sterility. 84:305-312
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- OBJECTIVE: To investigate the possible association between the body burden of dioxin-like compounds and endometriotic disease. DESIGN: Case-control study. SETTING: Gynecology ward in a university hospital. PATIENT(S): Seventy-one women with peritoneal endometriosis (n = 25) or deep endometriotic (adenomyotic) nodules (n = 25) and controls (n = 21). INTERVENTION(S): Collection of 200 mL of blood (fasted) and face-to-face interview. MAIN OUTCOME MEASURE(S): Assessment of dioxin (PCDD), furan (PCDF), and dioxin-like PCB serum concentrations (picograms toxic equivalent [TEQ]/g lipids). RESULT(S): Age and body mass index were traced by linear multiple regression as determinants of total TEQ levels. After standardization for these variables (30 years and 22.5 kg/m2), the mean TEQ levels were 24.21 (controls), 30.62 (peritoneal endometriosis), and 37.60 (deep endometriotic [adenomyotic] nodules) pg TEQ/g lipids. Logistic regression analysis indicated a significantly increased risk of deep endometriotic (adenomyotic) nodules (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.4-7.6) for an increment of 10 pg in total TEQ levels/g lipids. An increased risk was also found for peritoneal endometriosis (OR, 1.9; 95% CI, 0.9-3.8) for total TEQ levels and for dioxins alone (OR, 3.2; 95% CI, 1.0-9.9). CONCLUSION(S): The results provide the first epidemiological evidence of an association between increased PCDD/PCDF and PCB body burden and endometriosis.
- Subjects :
- Adult
medicine.medical_specialty
Endometriosis
Dioxins
Logistic regression
Statistics, Nonparametric
medicine
Humans
Gynecology
Chi-Square Distribution
business.industry
Case-control study
Obstetrics and Gynecology
Nodule (medicine)
Odds ratio
medicine.disease
Confidence interval
Logistic Models
Reproductive Medicine
Case-Control Studies
Female
Peritoneum
medicine.symptom
business
Body mass index
Chi-squared distribution
Subjects
Details
- ISSN :
- 00150282
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Fertility and Sterility
- Accession number :
- edsair.doi.dedup.....1135f6398c0efca3e7865cbed80ca5bf