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Acrolein and other toxicant exposures in relation to cardiovascular disease among marijuana and tobacco smokers in a longitudinal cohort of HIV-positive and negative adults
- Source :
- EClinicalMedicine, EClinicalMedicine, Vol 31, Iss, Pp 100697-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Background: Marijuana smoke contains some of the same toxicants present in tobacco smoke. Marijuana smoking is prevalent among HIV+ individuals, but few studies have characterized smoke-related toxicants or associated health outcomes in exclusive marijuana users. Methods: This longitudinal study included 245 participants over age 40 (76% HIV+). 33 plasma and 28 urine metabolites of nicotine, ∆-9-trans-tetrahydrocannabinol, polycyclic aromatic hydrocarbons, and volatile organic compounds were assayed by liquid or gas chromatography/mass spectrometry. Exposures and health outcomes were assessed from surveys and medical records. Findings: At baseline, 18% of participants were marijuana-only smokers, 20% tobacco-only smokers, and 24% dual marijuana-tobacco smokers (median (IQR) age 53 (47–60) years, 78% male, 54% white race). Marijuana smoking was independently associated with elevated plasma naphthalenes, 2-hydroxyfluorene sulfate, 4-vinylphenol sulfate, and o-cresol sulfate (p
- Subjects :
- Longitudinal study
Physiology
Disease
Urine
01 natural sciences
Tobacco smoke
Nicotine
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Smoke
mental disorders
Tobacco
Medicine
Toxicants
030212 general & internal medicine
0101 mathematics
Acrolein
lcsh:R5-920
business.industry
010102 general mathematics
General Medicine
Cardiovascular disease
Marijuana
chemistry
lcsh:Medicine (General)
business
medicine.drug
Toxicant
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 25895370
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- EClinicalMedicine
- Accession number :
- edsair.doi.dedup.....112fa9723f2a5fdd4b7593d084e5f610