Back to Search
Start Over
4-Methylcoumarins as antioxidants: Scavenging of peroxyl radicals and inhibition of human low-density lipoprotein oxidation
- Source :
- Biochimie. 92:1147-1152
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The antioxidant activity of eight synthetic 4-methylcoumarins was systematically studied. The antioxidant capacity was measured using: (i) a competition kinetic test, to measure the relative capacity to quench peroxyl radical; (ii) the in vitro oxidative modification of human low-density lipoprotein, initiated by AAPH or catalyzed by copper. In both models, the ortho-OH substitutes were found to be better antioxidant than the meta one. The most efficient antioxidant was the 7,8-dihydroxy-4-methylcoumarin and the corresponding diacetoxy-substituted was unexpectedly a good antioxidant. Finally, the presence of an ethoxycarbonylethyl substituent at the C-3 position increased the antioxidant capacity of both 7,8-dihydroxy-4-methylcoumarin and 7,8-diacetoxy-4-methylcoumarin.
- Subjects :
- Antioxidant
Molecular Structure
DPPH
medicine.medical_treatment
Substituent
General Medicine
Oxidative phosphorylation
Biochemistry
Antioxidants
In vitro
Peroxides
Lipoproteins, LDL
chemistry.chemical_compound
chemistry
Coumarins
Low-density lipoprotein
medicine
Humans
Structure–activity relationship
Organic chemistry
4-methylcoumarins
antioxidant activity
antioxidants
low density lipoprotein
low-density lipoproteins
scavengers
structure-activity relationship
Oxidation-Reduction
Lipoprotein
Subjects
Details
- ISSN :
- 03009084
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Biochimie
- Accession number :
- edsair.doi.dedup.....112ba94ccf17d39d5b170b01c5371166