Hospital-based antibiotic use in patients with Mycobacterium avium complex

Authors :: Jennifer Adjemian
Yi Ling Lai
Kenneth N. Olivier
Emily Ricotta
D. Rebecca Prevots
Source :: ERJ Open Research, Vol 4, Iss 4 (2018), ERJ Open Research
Publication Year :: 2018
Publisher :: European Respiratory Society (ERS), 2018.
Abstract: Treatment guidelines exist for pulmonary Mycobacterium avium complex (MAC) infection, although studies suggest poor concordance in clinician practice. Using a national database including hospital encounters of laboratory-confirmed MAC patients, we sought to characterise US treatment practices. We assessed patients in the Premier Healthcare Database from 2009 to 2013 with two or more MAC-positive cultures or one MAC-positive culture and the International Classification of Diseases (9th revision) code for pulmonary nontuberculous mycobacteria (PNTM). Treatment was characterised by patient-, provider- and facility-level factors; significant differences were assessed (p<br />Few MAC patients receive recommended therapy and improved treatment is needed to prevent resistance http://ow.ly/4F0S30lIihn