Back to Search
Start Over
The relationship between blood pressure, pulse pressure and right ventricular function following an atrial switch procedure for complete transposition of the great arteries
- Source :
- International Journal of Cardiology. 101:59-63
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- The pressure overload may be responsible for the failure of the systemic ventricle. No study so far has evaluated the association between arterial blood pressure values and right ventricular function in adults with atrially corrected complete transposition.This was a retrospective analysis. The studied population consisted of 60 patients with complete transposition, 11.5+/-2.7 years after atrial switch procedure, divided into subgroups according to the severity of systemic ventricular dysfunction (right ventricular ejection fractionor = 0.40 vs.0.40), and the severity of perfusion abnormalities in the radionuclide study (absent or mild vs. moderate-to-severe).All patients had blood pressure values (systolic 109.1+/-11.7 mm Hg and diastolic 72.3+/-9.7 mm Hg) within the normal range. Systolic blood pressure values correlated inversely with right ventricular ejection fraction (r = -0.450; p0.001). Compared to patients with systolic blood pressure below median values, patients with "elevated" blood pressure had lower right ventricular ejection fraction (32.6+/-6.3 vs. 38.9.+/-7.2; por = 0.002) and more significant perfusion abnormalities (1.5+/-1.0 vs. 2.9+/-1.5; por = 0.001). In a multivariate backward logistic regression model age at surgery and at the time of the study, systolic blood pressure at rest predicted impaired right ventricular ejection fraction (p0.02). Greater pulse pressure at peak exercise female sex were associated with greater more severe perfusion abnormalities (p0.01).There is a significant correlation between blood pressure values and indices of right ventricular dysfunction in patients who underwent an atrial switch procedure for complete transposition. Blood pressure values might be considered as a surrogate end point in these patients.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Transposition of Great Vessels
Ventricular Dysfunction, Right
Diastole
Blood Pressure
Severity of Illness Index
Internal medicine
medicine
Humans
Heart Atria
Postoperative Period
Pulse
Retrospective Studies
business.industry
Central venous pressure
Stroke Volume
Transposition of the great vessels
medicine.disease
Pulse pressure
Treatment Outcome
medicine.anatomical_structure
Blood pressure
Ventricle
Circulatory system
Ventricular Function, Right
Ventricular pressure
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....11188f23bb0927d8f1ffb5c5f81852fc