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Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus invasive coronary angiography
- Source :
- Journal of Nuclear Cardiology, Journal of Nuclear Cardiology, Springer Verlag, 2015, 22 (3), pp.513-522. ⟨10.1007/s12350-014-0016-0⟩, Journal of Nuclear Cardiology, 2015, 22 (3), pp.513-522. ⟨10.1007/s12350-014-0016-0⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- Recent advances in nuclear myocardial perfusion imaging (MPI) have made it possible to develop a dual-isotope protocol for high-speed acquisition with image quality and radiation delivery comparable to that obtained with conventional single isotope protocols. So far, no study has compared dual-isotope high-speed MPI to invasive coronary angiography (ICA) in a large cohort using a Cadmium-zinc-telluride SPECT system. Over a 1-year period (May 2011 to April 2012), 1366 patients underwent dual-isotope high-speed MPI. Patients with ICA within 3 months after dual-isotope high-speed MPI were included together with patients with a low likelihood of coronary artery disease (CAD) in order to assess normalcy rate. Global summed stress score (SSS) and summed rest score (SRS) were calculated, and ICA results were analyzed independently. The main end point was a patient-based assessment of the diagnostic performance of dual-isotope high-speed MPI in detecting or ruling out significant CAD (>70% reduction in lumen diameter). Inclusion criteria were fulfilled for 214 patients (143 men; age 60 ± 14 years; ICA, n = 104; low likelihood for CAD, n = 110). An exercise stress test was performed in 62% of patients and a pharmacological stress test was performed with either dipyridamole (32%) or dobutamine (6%). Average examination duration was 22.4 ± 4.5 minutes. Mean SSS, SRS, and SDS were 8.0 ± 4.9, 3.1 ± 4.3, and 5.0 ± 3.2, respectively. Prevalence of angiographic CAD was 75%. ICA detected stenosis in the left main trunk, left anterior descending artery, left circumflex artery, and right coronary artery in 4, 33, 31, and 42 patients, respectively. Sensitivity of dual-isotope high-speed MPI was 94%, normalcy rate was 92%, and accuracy was 83% for detecting CAD. Dual-isotope high-speed MPI is reliable at detecting or ruling out CAD. NCT01785589
- Subjects :
- Male
Myocardial Infarction
Perfusion scanning
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
030218 nuclear medicine & medical imaging
Cohort Studies
Coronary artery disease
Ventricular Dysfunction, Left
0302 clinical medicine
Coronary Artery Bypass
ComputingMilieux_MISCELLANEOUS
Aged, 80 and over
medicine.diagnostic_test
Myocardial Perfusion Imaging
Middle Aged
3. Good health
Dipyridamole
Zinc
Right coronary artery
Female
Tellurium
Cardiomyopathies
Cardiology and Cardiovascular Medicine
Cadmium
medicine.drug
Adult
Technetium Tc 99m Sestamibi
Rest
[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine
Sensitivity and Specificity
[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine
03 medical and health sciences
Myocardial perfusion imaging
medicine.artery
medicine
Humans
Radiology, Nuclear Medicine and imaging
Angina, Unstable
Aged
Tomography, Emission-Computed, Single-Photon
business.industry
medicine.disease
SSS
Thallium Radioisotopes
Stenosis
Exercise Test
Dobutamine
Nuclear Medicine
Radiopharmaceuticals
Nuclear medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 10713581
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Cardiology, Journal of Nuclear Cardiology, Springer Verlag, 2015, 22 (3), pp.513-522. ⟨10.1007/s12350-014-0016-0⟩, Journal of Nuclear Cardiology, 2015, 22 (3), pp.513-522. ⟨10.1007/s12350-014-0016-0⟩
- Accession number :
- edsair.doi.dedup.....11161df7ea35f787cd89fea30ceb6d52