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Expression pattern analysis of IRF4 and its related genes revealed the functional differentiation of IRF4 paralogues in teleost
- Source :
- Fishshellfish immunology. 60
- Publication Year :
- 2016
-
Abstract
- In mammals, interferon regulatory factor 4 (IRF4) plays an important role in the process of development and differentiation of B cells, T cells and dendritic cells. It can regulate immune pathway through IRF5, MyD88, IL21, PGC1α, and NOD2. In the present study, we investigated the expression pattern of IRF4 paralogues and these related genes for the first time in teleosts. The results showed that these genes were all expressed predominantly in known immune tissues while IRF5 was also relatively highly expressed in muscle. IRF4b, IL21, MyD88, IRF5 and NOD2 showed maternal expression in the oocyte and the higher expression of IRF4a, Mx and PGC1α before hatching might be involved in the embryonic innate defense system. Zebrafish embryonic fibroblast (ZF4) cells were infected with GCRV and SVCV. During GCRV infection, the expression of Mx was significantly up-regulated from 3 h to 24 h, reaching the highest level at 12 h (101.5-fold over the controls, P
- Subjects :
- 0301 basic medicine
Aquatic Science
Biology
Reoviridae
Cell Line
03 medical and health sciences
Fish Diseases
0302 clinical medicine
Immune system
NOD2
Rhabdoviridae Infections
medicine
Environmental Chemistry
Animals
Fibroblast
Gene
Zebrafish
Phylogeny
Genetics
General Medicine
Sequence Analysis, DNA
Zebrafish Proteins
biology.organism_classification
Embryonic stem cell
Molecular biology
Immunity, Innate
Reoviridae Infections
030104 developmental biology
medicine.anatomical_structure
Gene Expression Regulation
030220 oncology & carcinogenesis
Interferon Regulatory Factors
Rhabdoviridae
IRF5
IRF4
Subjects
Details
- ISSN :
- 10959947
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Fishshellfish immunology
- Accession number :
- edsair.doi.dedup.....1103c559ad59ffa3462274ce18b604e9