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Aspirin Resistance in Hypertensive Patients
- Source :
- J Clin Hypertens (Greenwich)
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Aspirin resistance is associated with poor clinical prognosis. The authors investigated aspirin resistance in 200 hypertensive patients (111 men, age: 68.3 +/- 11.4 years) by the Ultegra Rapid Platelet Function Assay-ASA (Accumetrics Inc., San Diego, CA). Aspirin resistance was defined as an aspirin reaction unit >= 550. Aspirin resistance was detected in 42 patients. Aspirin resistance was present in 25.6% of the patients with poor blood pressure control, while in 17.8% of the patients with controlled blood pressure (P=.182). Female gender and creatinine levels were significantly higher (P=.028 and P=.030, respectively), while platelet count was significantly lower (P=.007) in aspirin-resistant patients. Multivariate analysis revealed that female gender (odds ratio [OR], 2.445; P=.045), creatinine levels (OR, 1.297; P=.015) and platelet count (OR, 0.993; P=.005) were independent predictors of aspirin resistance. The frequency of aspirin resistance is not low in hypertensive patients. Female hypertensive patients, especially, with higher creatinine levels and lower platelet count are at higher risk for aspirin resistance. J Clin Hypertens (Greenwich). 2010; 12: 714-720. (C) 2010 Wiley Periodicals, Inc.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Drug Resistance
BLOOD-PRESSURE
Drug resistance
Gastroenterology
law.invention
chemistry.chemical_compound
Randomized controlled trial
law
Internal medicine
PLATELET RESPONSE
NONRESPONSIVENESS
Internal Medicine
medicine
Humans
Platelet
ASPIRIN RESISTANCE
Aged
IIIA POLYMORPHISM
Aspirin
Creatinine
business.industry
LOW-DOSE ASPIRIN
DIABETES-MELLITUS
IN-VITRO
Odds ratio
Middle Aged
Original Papers
PREVENTION
PREVALENCE
Surgery
Treatment Outcome
Blood pressure
chemistry
Hypertension
RISK-FACTORS
Female
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 15246175
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Hypertension
- Accession number :
- edsair.doi.dedup.....1103835e7415656be3f0a0d434d2679a
- Full Text :
- https://doi.org/10.1111/j.1751-7176.2010.00307.x