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Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun
- Source :
- Oncology Letters
- Publication Year :
- 2018
- Publisher :
- Spandidos Publications, 2018.
-
Abstract
- Osteosarcoma is a mesenchymally derived, high-grade bone sarcoma that is the most frequently diagnosed primary malignant bone tumor. Today, chemoprevention is regarded as a promising and realistic approach in the prevention of human cancer. Previous studies have suggested ellagic acid (EA) and Sennoside B have potential in this regard. The aim of the present study was to elucidate the anti-osteosarcoma effects of EA and Sennoside B by using Saos-2 and MG63 osteosarcoma cells. It was identified that EA or Sennoside B treatment could inhibit the growth, migration and invasion of the cells, and induce G1 cell cycle arrest by repressing the transcription of c-Jun. These results may provide a cellular basis for the application of EA or Sennoside B in the treatment of patients with osteosarcoma.
- Subjects :
- 0301 basic medicine
Cancer Research
growth
Cell
migration
03 medical and health sciences
0302 clinical medicine
ellagic acid
osteosarcoma
medicine
Oncogene
Chemistry
c-Jun
c-jun
Cell migration
Articles
Cell cycle
medicine.disease
sennoside B
030104 developmental biology
medicine.anatomical_structure
Oncology
Apoptosis
030220 oncology & carcinogenesis
Cancer research
Osteosarcoma
G1 phase
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....10e9f993a3844e186d62e8c50d12da89