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The association between depressive symptoms and neurocognitive impairment in people with well-treated HIV in Switzerland
- Source :
- International Journal of STD & AIDS. 32:729-739
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- Background: Depression may contribute to neurocognitive impairment (NCI) in people with HIV (PWH). Attributing NCI to depression rather than to HIV is complicated as depression may be both a causal factor and an effect of NCI. This study aimed to determine the association between depressive symptoms and NCI among PWH with well-controlled infection. Methods: The Neurocognitive Assessment in the Metabolic and Ageing Cohort study is an ongoing, prospective, longitudinal study of PWH aged ≥45 years old nested within the Swiss HIV Cohort Study. Neurocognitive Assessment in the Metabolic and Ageing Cohort study participants underwent neurocognitive assessment and grading of depressive symptoms using the Centre for Epidemiological Studies Depression Scale. Neurocognitive impairment categories were defined using Frascati criteria. Participants with NCI related to neurological or psychiatric confounders other than depression were excluded. The cross-sectional association between the Centre for Epidemiological Studies Depression score and neurocognitive impairment was examined taking Centre for Epidemiological Studies Depression score as a continuous variable and then as a binary variable using two score thresholds, 16 and 27. Results: Excluding 79 participants with confounding factors, 902 participants were studied: 81% were men; 96% had plasma viral loads
- Subjects :
- Male
medicine.medical_specialty
Neurocognitive Disorders
Human immunodeficiency virus (HIV)
HIV Infections
Dermatology
Neuropsychological Tests
medicine.disease_cause
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
Pharmacology (medical)
Longitudinal Studies
Prospective Studies
030212 general & internal medicine
Psychiatry
Association (psychology)
Depressive symptoms
Depression (differential diagnoses)
Depression
business.industry
Public Health, Environmental and Occupational Health
Middle Aged
Cross-Sectional Studies
Infectious Diseases
Female
Neuropsychological testing
business
Neurocognitive
Switzerland
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17581052 and 09564624
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- International Journal of STD & AIDS
- Accession number :
- edsair.doi.dedup.....10e7bbd7d48ddce9b52ab617da90623f