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Functional and Mechanistic Studies of Two Anti-coccidial Herbs, Bidens pilosa and Artemisia indica
- Source :
- Planta Medica. 88:282-291
- Publication Year :
- 2021
- Publisher :
- Georg Thieme Verlag KG, 2021.
-
Abstract
- Currently, antibiotics are commonly used to treat coccidiosis, a severe protozoal disease in chickens. However, due to growing concerns about the antibiotic residue in meat and eggs, phytogenic formulations are becoming an attractive approach to manage this disease. In this study, we investigated the anti-coccidial function and mechanism of phytogenic formulations composed of Bidens pilosa, Artemisia indica, and both used in combination. We found that these formulations increased the survival rate and reduced body weight loss, the feed conversion ratio, oocyst excretion, bloody stools, and gut lesions of chickens. Mechanistic studies showed that A. indica, but not B. pilosa, reduced the survival of Eimeria oocysts. Accordingly, they both inhibited oocyst sporulation and sporozoite invasion into Madin-Darby bovine kidney (MDBK) cells. Overall, we demonstrate that these formulations protect chickens against coccidiosis. Moreover, a combination of B. pilosa and A. indica has an additive effect on coccidiosis control and growth performance in chickens compared to either one used alone.
- Subjects :
- 0301 basic medicine
medicine.drug_class
Antibiotics
0211 other engineering and technologies
Pharmaceutical Science
02 engineering and technology
Biology
Feed conversion ratio
Eimeria
Analytical Chemistry
Excretion
03 medical and health sciences
parasitic diseases
021105 building & construction
Drug Discovery
medicine
Artemisia indica
Animals
Bidens
Poultry Diseases
Pharmacology
Traditional medicine
Coccidiosis
Organic Chemistry
food and beverages
medicine.disease
biology.organism_classification
Spore
030104 developmental biology
Artemisia
Complementary and alternative medicine
Bidens pilosa
Molecular Medicine
Cattle
Chickens
Subjects
Details
- ISSN :
- 14390221 and 00320943
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Planta Medica
- Accession number :
- edsair.doi.dedup.....10db63a272c40b92fe4487ee9ff49bb1